Tocilizumab not associated with increased infection risk after CAR T-cell therapy: implications for COVID-19?

Author:

Frigault Matthew J.1,Nikiforow Sarah2,Mansour Michael K.3ORCID,Hu Zhen-Huan4,Horowitz Mary M.45,Riches Marcie L.6ORCID,Hematti Peiman7,Turtle Cameron J.8,Zhang Mei-Jie4,Perales Miguel-Angel9,Pasquini Marcelo C.45ORCID

Affiliation:

1. Cellular Immunotherapy Program, Massachusetts General Hospital, Boston, MA;

2. Division of Hematologic Malignancies, Department of Medicine, Dana-Farber Cancer Institute, Boston, MA;

3. Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA;

4. Center for International Blood and Marrow Transplant Research and

5. Blood and Marrow Transplant and Cellular Therapy Program, Medical College of Wisconsin, Milwaukee, WI;

6. Division of Hematology/Oncology, Department of Medicine, University of North Carolina, Chapel Hill, NC;

7. Division of Hematology/Oncology/Bone Marrow Transplantation, Department of Medicine, University of Wisconsin, Madison, WI;

8. Department of Medicine, University of Washington, Seattle, WA; and

9. Adult Blood and Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference21 articles.

1. Covid-19 in critically ill patients in the Seattle region - case series;Bhatraju;N Engl J Med,2020

2. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study;Zhou;Lancet,2020

3. State of the art in CAR T cell therapy for CD19+ B cell malignancies;Frigault;J Clin Invest,2020

4. Clinical and immunologic features in severe and moderate coronavirus disease 2019;Chen;J Clin Invest,2020

5. Clinical characteristics of 3,062 COVID-19 patients: a meta-analysis [published online ahead of print 15 April 2020];Zhu;J Med Virol

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