Low iron promotes megakaryocytic commitment of megakaryocytic-erythroid progenitors in humans and mice-Reference-Cited by-同舟云学术

Low iron promotes megakaryocytic commitment of megakaryocytic-erythroid progenitors in humans and mice

Published:2019-08-22 Issue:18 Volume:134 Page:1547-1557
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Xavier-Ferrucio Juliana¹²,Scanlon Vanessa¹²^ORCID,Li Xiuqi³,Zhang Ping-Xia¹²,Lozovatsky Larisa³,Ayala-Lopez Nadia¹²^ORCID,Tebaldi Toma⁴⁵⁶^ORCID,Halene Stephanie²⁴⁵⁶^ORCID,Cao Chang⁷,Fleming Mark D.⁷^ORCID,Finberg Karin E.³^ORCID,Krause Diane S.¹²³^ORCID

Affiliation:

1. Department of Laboratory Medicine,

2. Yale Stem Cell Center,

3. Department of Pathology,

4. Section of Hematology, Department of Internal Medicine,

5. Yale Comprehensive Cancer Center, and

6. Yale Center for RNA Science and Medicine, Yale School of Medicine, New Haven, CT; and

7. Department of Pathology, Boston Children’s Hospital, Boston, MA

Abstract

Xavier-Ferrucio and colleagues elucidate the mechanism of thrombocytosis in iron deficiency anemia, using murine and human cell models to demonstrate that iron deficiency attenuates ERK signaling and biases the commitment of megakaryocyte-erythrocyte progenitors toward the megakaryocytic lineage.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/134/18/1547/1504085/bloodbld2019002039.pdf

Reference44 articles.

1. Iron deficiency anemia: a common and curable disease;Miller;Cold Spring Harb Perspect Med,2013

2. Thrombocytosis in iron deficiency anemia;Dan;Intern Med,2005

3. Hepcidin and iron homeostasis;Ganz;Biochim Biophys Acta,2012

4. Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA);Finberg;Nat Genet,2008

5. The serine protease TMPRSS6 is required to sense iron deficiency;Du;Science,2008

Cited by 55 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Indicators of iron metabolism in regular donors of blood platelets and plasma;Russian journal of hematology and transfusiology;2024-08-18

2. Iron deficiency anemia and platelet dysfunction: A comprehensive analysis of the underlying mechanisms;Life Sciences;2024-08

3. Thrombocytosis and megakaryocyte changes associated with PRCA;Blood Advances;2024-06-12

4. HBV-mediated Suppression of Megakaryocyte Differentiation through UBE4B Upregulation and Modulation of p53 and ERK1/2;2024-04-02

5. Effect of ferric citrate hydrate on fibroblast growth factor 23 and platelets in non-dialysis-dependent chronic kidney disease and non-chronic kidney disease patients with iron deficiency anemia;Clinical and Experimental Nephrology;2024-02-25