Cerebral venous thrombosis due to vaccine-induced immune thrombotic thrombocytopenia after a second ChAdOx1 nCoV-19 dose-Reference-Cited by-同舟云学术

Cerebral venous thrombosis due to vaccine-induced immune thrombotic thrombocytopenia after a second ChAdOx1 nCoV-19 dose

Published:2022-04-28 Issue:17 Volume:139 Page:2720-2724
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Krzywicka Katarzyna¹^ORCID,van de Munckhof Anita¹^ORCID,Zimmermann Julian²^ORCID,Bode Felix J.²^ORCID,Frisullo Giovanni³^ORCID,Karapanayiotides Theodoros⁴^ORCID,Pötzsch Bernd⁵,Sánchez van Kammen Mayte¹,Heldner Mirjam R.⁶^ORCID,Arnold Marcel⁶,Kremer Hovinga Johanna A.⁷^ORCID,Ferro José M.⁸^ORCID,Aguiar de Sousa Diana⁹^ORCID,Coutinho Jonathan M.¹^ORCID

Affiliation:

1. Department of Neurology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands;

2. Department of Neurology, Universitätsklinikum Bonn, Bonn, Germany;

3. Department of Neurology, Fondazione Policlinico Universitario Agostino Gemelli Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy;

4. Second Department of Neurology, School of Medicine and Faculty of Health Sciences, Aristotle University of Thessaloniki, American Hellenic Educational Progressive Association University Hospital, Thessaloniki, Greece;

5. Institute of Experimental Hematology and Transfusion Medicine, Universitätsklinikum Bonn, Bonn, Germany;

6. Department of Neurology and

7. Department of Hematology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; and

8. Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, and

9. Department of Neurosciences and Mental Health, Hospital de Santa Maria, Centro Hospitalar Universitario Lisboa Norte, Universidade de Lisboa, Lisbon, Portugal

Abstract

Vaccine-induced immune thrombotic thrombocytopenia (VITT), a rare but life-threatening complication of adenoviral vaccination against COVID-19, has been reported almost entirely following the first dose. Krzywicka and colleagues report on 124 patients with VITT in a multinational registry diagnosed after dose 2; no specific events were observed after dose 1. These patients had early presentation, and two of the patients died.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

https://ashpublications.org/blood/article-pdf/139/17/2720/1894737/bloodbld2021015329.pdf

Reference16 articles.

1. Thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination;Greinacher;N Engl J Med.,2021

2. Pathologic antibodies to platelet factor 4 after ChAdOx1 nCoV-19 vaccination;Scully;N Engl J Med.,2021

3. Thrombosis and thrombocytopenia after ChAdOx1 nCoV-19 vaccination;Schultz;N Engl J Med.,2021

4. Characteristics and outcomes of patients with cerebral venous sinus thrombosis in SARS-CoV-2 vaccine-induced immune thrombotic thrombocytopenia;Sánchez van Kammen;JAMA Neurol.,2021

5. Clinical features of vaccine-induced immune thrombocytopenia and thrombosis;Pavord;N Engl J Med.,2021

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