Genetic characterization of B-cell prolymphocytic leukemia: a prognostic model involving MYC and TP53-Reference-Cited by-同舟云学术

Genetic characterization of B-cell prolymphocytic leukemia: a prognostic model involving MYC and TP53

Published:2019-09-16 Issue: Volume: Page:
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Chapiro Elise¹^ORCID,Pramil Elodie²,Diop M'boyba³,Roos-Weil Damien⁴^ORCID,Dillard Clémentine²,Gabillaud Clémentine¹,Maloum Karim⁵^ORCID,Settegrana Catherine⁶,Baseggio Lucile⁷^ORCID,Lesesve Jean-François⁸,Yon Mélanie²,Jondreville Ludovic⁹,Lesty Claude¹⁰,Davi Frederic B¹⁰^ORCID,Le Garff-Tavernier Magali¹^ORCID,Droin Nathalie M¹¹,DESSEN Philippe³,Algrin Caroline¹²,Leblond Veronique¹³,Gabarre Jean¹⁴,Bouzy Simon¹,eclache virginie¹⁵,Gaillard Baptiste¹⁶,Callet-Bauchu Evelyne¹⁷,Muller Marc¹⁸,LEFEBVRE Christine¹⁹,NADAL Nathalie²⁰,Ittel Antoine²¹,Struski Stephanie²²,Collonge-Rame Marie-Agnès²³,QUILICHINI BENOIT²⁴,Fert-Ferrer Sandra²⁵,Auger Nathalie²⁶,Radford-Weiss Isabelle²⁷,Wagner Lena²⁸,Scheinost Sebastian²⁹,Zenz Thorsten³⁰,Susin Santos A.²^ORCID,Bernard Olivier A³¹,Nguyen-Khac Florence¹³^ORCID

Affiliation:

1. AP-HP, PARIS, France

2. Sorbonne Université, Paris, France

3. Gustave Roussy, Villejuif, France

4. Pitié-Salpêtrière, paris, France

5. Pitie-salpetriere Hospital, Paris, France

6. Pitie-Salpetriere Hospital, Paris, Paris, France

7. Hospices Civils de LYON/Groupement Hospitalier Sud, PIERRE BENITE, France

8. Service d'hématologie biologique, CHRU Nancy

9. CR Cordeliers, Paris, France

10. AP-HP, Hôpital Pitié-Salpêtrière, Paris, France

11. INSERM U1170, Gustave Roussy, VILLEJUIF, France

12. Groupe Hospitalier Mutualiste de Grenoble, Grenoble, France

13. Hopital Pitie-Salpetriere, Paris, France

14. AP-HP, Pitié-Salpêtrière-Charles Foix University Hospital

15. APHP, bobigny, France

16. Hôpital Robert Debré, Reims, France

17. Hospices Civils de Lyon, Pierre-Bénite, France

18. CHRU Nancy, Genetic laboratory, VANDOEUVRE LES NANCY, France

19. CHU GRENOBLE, Grenoble, France

20. University hospital of Dijon, DIJON, France

21. CHU Strasbourg, Strasbourg, France

22. IUC Oncopole, Toulouse, France

23. CHRU Besançon, Besançon, France

24. LABORATOIRE EUROFINS BIOMNIS, LYON, France

25. Centre Hospitalier Métropole Savoie, Chambéry, France

26. Institute Gustave Roussy, Villejuif, France

27. Hôpital Necker Enfants M, PARIS, France

28. DKFZ, Heidelberg, Germany

29. NCT Heidelberg, Heidelberg, Germany

30. University of Zurich, Zürich, Switzerland

31. INSERM, Villejuif cedex, France

Abstract

Key Points B-PLL is tightly linked to MYC aberrations (translocation or gain) and 17p (TP53) deletion. Cases of B-PLL with MYC aberration and 17p (TP53) deletion have the worst prognosis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/doi/10.1182/blood.2019001187/1222506/blood.2019001187.pdf

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