Outcomes of older patients in ZUMA-1, a pivotal study of axicabtagene ciloleucel in refractory large B-cell lymphoma-Reference-Cited by-同舟云学术

Outcomes of older patients in ZUMA-1, a pivotal study of axicabtagene ciloleucel in refractory large B-cell lymphoma

Published:2020-06-04 Issue:23 Volume:135 Page:2106-2109
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Neelapu Sattva S.¹^ORCID,Jacobson Caron A.²,Oluwole Olalekan O.³^ORCID,Munoz Javier⁴,Deol Abhinav⁵,Miklos David B.⁶^ORCID,Bartlett Nancy L.⁷⁸,Braunschweig Ira⁹,Jiang Yizhou¹⁰,Kim Jenny J.¹⁰,Zheng Lianqing¹⁰,Rossi John M.¹⁰,Locke Frederick L.¹¹

Affiliation:

1. Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX;

2. Hematologic Oncology Treatment Center, Dana-Farber Cancer Institute, Boston, MA;

3. Division of Hematology and Oncology, Vanderbilt-Ingram Cancer Center, Nashville, TN;

4. Department of Lymphoma/Myeloma, Banner MD Anderson Cancer Center, Gilbert, AZ;

5. Karmanos Cancer Center, Department of Oncology, Wayne State University, Detroit, MI;

6. Division of Blood and Marrow Transplantation, Stanford University School of Medicine, Stanford, CA;

7. Department of Medicine, Washington University School of Medicine, St. Louis, MO;

8. Siteman Cancer Center, St. Louis, MO;

9. Montefiore Medical Center, Department of Oncology, Albert Einstein College of Medicine, Bronx, NY;

10. Kite, a Gilead Company, Santa Monica, CA; and

11. Department of Blood and Marrow Transplant and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, FL

Abstract

Neelapu and colleagues report a post hoc subgroup analysis from the ZUMA-1 trial of chimeric antigen receptor T-cell therapy for relapsed or refractory diffuse large B cell lymphoma. In comparison with younger patients, those ≥65 years old have similar rates of complete response and durable response at 2 years, but higher rates of neurological toxicity.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/135/23/2106/1743262/bloodbld2019004162.pdf

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