Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GVHD

Author:

Koehn Brent H.1ORCID,Saha Asim1,McDonald-Hyman Cameron1,Loschi Michael1,Thangavelu Govindarajan1,Ma Lie1,Zaiken Michael1ORCID,Dysthe Josh1,Krepps Walker1,Panthera Jamie1,Hippen Keli1ORCID,Jameson Stephen C.23,Miller Jeffrey S.4,Cooper Matthew A.5,Farady Christopher J.6,Iwawaki Takao7ORCID,Ting Jenny P.-Y.891011ORCID,Serody Jonathan S.891011ORCID,Murphy William J.1213,Hill Geoffrey R.1415,Murray Peter J.1617,Bronte Vincenzo18,Munn David H.19,Zeiser Robert2021,Blazar Bruce R.12ORCID

Affiliation:

1. Division of Blood and Marrow Transplantation, Department of Pediatrics,

2. Center for Immunology,

3. Department of Laboratory Medicine and Pathology,

4. Department of Medicine, University of Minnesota, Minneapolis, MN;

5. Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia;

6. Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research, Basel, Switzerland;

7. Division of Cell Medicine, Department of Life Science, Medical Research Institute, Kanazawa Medical University, Ishikawa, Japan;

8. Lineberger Comprehensive Cancer Center,

9. Inflammatory Diseases Institute,

10. Department of Genetics,

11. Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC;

12. Department of Dermatology,

13. Department of Internal Medicine, School of Medicine, University of California Davis, Sacramento, CA;

14. QIMR Berghofer Medical Research Institute, Brisbane, Australia;

15. Department of Bone Marrow Transplantation, Royal Brisbane and Women’s Hospital, Brisbane, Australia;

16. Department of Infectious Diseases,

17. Department of Immunology, St Jude Children’s Research Hospital, Memphis, TN;

18. Dipartimento di Afferenza Medicina, Verona University, Verona, Italy;

19. Cancer Center, Department of Pediatrics, Georgia Regent’s University, Augusta, GA;

20. Department of Hematology and Oncology, Freiburg University Medical Center, Albert Ludwigs University, Freiburg, Germany; and

21. BIOSS Centre for Biological Signaling Studies, Freiburg, Germany

Abstract

These studies demonstrate how activation of the NLRP3 inflammasome pathway influences the function of myeloid-derived suppressor cells (MDSCs) in the setting of acute graft-versus-host disease (aGVHD).

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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