Splenic iron decreases without change in volume or liver parameters during luspatercept therapy-Reference-Cited by-同舟云学术

Splenic iron decreases without change in volume or liver parameters during luspatercept therapy

Published:2023-11-30 Issue:22 Volume:142 Page:1932-1934
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Denton Christopher C.¹²^ORCID,Vodala Sadanand³,Veluswamy Saranya¹²,Hofstra Thomas C.¹²,Coates Thomas D.¹²^ORCID,Wood John C.²⁴^ORCID

Affiliation:

1. 1Division of Hematology/Oncology, Department of Pediatrics, Children’s Hospital Los Angeles, Los Angeles, CA

2. 2Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA

3. 3Bristol Myers Squibb, Summit, NJ

4. 4Division of Cardiology, Department of Pediatrics, Children’s Hospital Los Angeles, Los Angeles, CA

Abstract

Abstract Splenic iron decreased whereas liver iron was stable during luspatercept therapy in some individuals with thalassemia. This suggests a reduction of ineffective erythropoiesis changes the organ distribution of iron and demonstrates that liver iron concentration alone may not accurately reflect total body iron content. This article describes data from subjects enrolled in BELIEVE (NCT02604433) and BEYOND (NCT03342404).

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

https://ashpublications.org/blood/article-pdf/142/22/1932/2091051/blood_bld-2023-021839-main.pdf

Reference16 articles.

1. Beta-thalassemias;Taher;N Engl J Med,2021

2. A phase 3 trial of luspatercept in patients with transfusion-dependent beta-thalassemia;Cappellini;N Engl J Med,2020

3. Hepatic iron concentration and total body iron stores in thalassemia major;Angelucci;N Engl J Med,2000

4. The use of luspatercept for thalassemia in adults;Cappellini;Blood Adv,2021

5. Luspatercept for the treatment of anaemia in non-transfusion-dependent beta-thalassaemia (BEYOND): a phase 2, randomised, double-blind, multicentre, placebo-controlled trial;Taher;Lancet Haematol,2022

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