Use of convalescent plasma in hospitalized patients with COVID-19: case series

Author:

Hegerova Livia1ORCID,Gooley Ted A.2,Sweerus Kelly A.3,Maree Cynthia4,Bailey Neil1ORCID,Bailey Megumi1,Dunleavy Vanessa1,Patel Krish1,Alcorn Kirsten5,Haley Rebecca5,Johnsen Jill M.56,Konkle Barbara A.56ORCID,Lahti Annamarie C.7,Alexander Morgan L.7,Goldman Jason D.4ORCID,Lipke Anne3,Lim Sun-jung3,Sullivan Mark D.3,Pauk John S.4,Pagel John M.1

Affiliation:

1. Center for Blood Disorders and Stem Cell Transplantation, Swedish Cancer Institute, Seattle, WA;

2. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA;

3. Division of Pulmonary and Critical Care and

4. Division of Infectious Disease, Department of Internal Medicine, Swedish Medical Center, Seattle, WA;

5. Bloodworks Northwest, Seattle, WA;

6. Division of Hematology, University of Washington, Seattle, WA; and

7. Neuroscience Institute, Swedish Medical Center, Seattle, WA

Abstract

Two case series examining the impact of convalescent plasma on patients with COVID-19 suggest some clinical benefit from early administration and modest impact on parameters of inflammation. Further assessment of the impact of this intervention awaits controlled clinical trials.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference24 articles.

1. World Health Organization . Coronavirus disease (COVID-19) pandemic. Available at: https://www.who.int/emergencies/diseases/novel-coronavirus-2019. Accessed 25 May 2020.

2. An interactive web-based dashboard to track COVID-19 in real time;Dong;Lancet Infect Dis,2020

3. Treatment with convalescent plasma for critically ill patients with severe acute respiratory syndrome coronavirus 2 infection [published online ahead of print 31 March 2020];Zhang;Chest

4. Convalescent plasma to treat COVID-19: possibilities and challenges;Roback;JAMA,2020

5. Effectiveness of convalescent plasma therapy in severe COVID-19 patients;Duan;Proc Natl Acad Sci USA,2020

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