ILROG emergency guidelines for radiation therapy of hematological malignancies during the COVID-19 pandemic

Author:

Yahalom Joachim1,Dabaja Bouthaina Shbib2,Ricardi Umberto3,Ng Andrea4,Mikhaeel N. George5ORCID,Vogelius Ivan R.6ORCID,Illidge Tim7,Qi Shunan8,Wirth Andrew9,Specht Lena6ORCID

Affiliation:

1. Memorial Sloan Kettering Cancer Center, New York, NY;

2. MD Anderson Cancer Center, Houston, TX;

3. Department of Oncology, University of Turin, Turin, Italy;

4. Dana-Farber Cancer Institute, Boston, MA;

5. Guy’s & St Thomas’ Hospital, London, United Kingdom;

6. Rigshospitalet, University of Copenhagen, Copenhagen, Denmark;

7. National Institute for Health Research (NIHR) Manchester Biomedical Research Centre, The University of Manchester, Christie National Health Service (NHS) Foundation Trust, Manchester, United Kingdom;

8. National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China; and

9. Peter MacCallum Cancer Institute, Melbourne, VIC, Australia

Abstract

Abstract The International Lymphoma Radiation Oncology Group (ILROG) guidelines for using radiation therapy (RT) in hematological malignancies are widely used in many countries. The emergency situation created by the COVID-19 pandemic may result in limitations of treatment resources. Furthermore, in recognition of the need to also reduce the exposure of patients and staff to potential infection with COVID-19, the ILROG task force has made recommendations for alternative radiation treatment schemes. The emphasis is on maintaining clinical efficacy and safety by increasing the dose per fraction while reducing the number of daily treatments. The guidance is informed by adhering to acceptable radiobiological parameters and clinical tolerability. The options for delaying or omitting RT in some hematological categories are also discussed.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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