Menin dependence: UBTF-ITD AML joins the club
Author:
Affiliation:
1. Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, and Abramson Cancer Center
Publisher
American Society of Hematology
Link
https://ashpublications.org/blood/article-pdf/143/7/567/2213675/blood_bld-2023-023041-c-main.pdf
Reference10 articles.
1. Acute myeloid leukemias with UBTF tandem duplications are sensitive to menin inhibitors;Barajas;Blood,2024
2. Integrated genomic analysis identifies UBTF tandem duplications as a recurrent lesion in pediatric acute myeloid leukemia;Umeda;Blood Cancer Discov,2022
3. Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia;Grembecka;Nat Chem Biol,2012
4. MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia;Riedel;J Clin Invest,2016
5. Targeting chromatin regulators inhibits leukemogenic gene expression in NPM1 mutant leukemia;Kühn;Cancer Discov,2016
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