Dysfunctional endogenous FIX impairs prophylaxis in a mouse hemophilia B model-Reference-Cited by-同舟云学术

Dysfunctional endogenous FIX impairs prophylaxis in a mouse hemophilia B model

Published:2019-05-30 Issue:22 Volume:133 Page:2445-2451
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Cooley Brian¹,Broze George J.²,Mann David M.³,Lin Feng-Chang⁴,Pedersen Lee G.⁵,Stafford Darrel W.⁶

Affiliation:

1. Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC;

2. Department of Medicine, Division of Medicine, Washington University in St. Louis, St. Louis, MO;

3. Mann BioConsulting, Gaithersburg, MD;

4. Department of Biostatistics,

5. Department of Chemistry, and

6. Department of Biology and Pathology, University of North Carolina at Chapel Hill, Chapel Hill, NC

Abstract

Key Points An endogenous, dysfunctional (CRM+) FIX molecule affects prophylactic FIX efficacy. Recovery studies indicate the amount of extravascular, Col4-bound FIX is several fold greater than the FIX in plasma.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/133/22/2445/1500120/blood884015.pdf

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