Asciminib: a new therapeutic option in chronic-phase CML with treatment failure

Author:

Yeung David T.123ORCID,Shanmuganathan Naranie123ORCID,Hughes Timothy P.123

Affiliation:

1. 1Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, Australia;

2. 2Adelaide Medical School, University of Adelaide, Adelaide, Australia; and

3. 3Haematology Department, Royal Adelaide Hospital, Adelaide, Australia

Abstract

Abstract Asciminib, a first-in-class allosteric inhibitor of BCR::ABL1 kinase activity, is now approved for the treatment of patients with chronic-phase chronic myeloid leukemia who failed 2 lines of therapy or in patients with the T315I mutation. Promising attributes include high specificity and potency against BCR::ABL1, activity against most kinase domain mutations, and potential for combination therapy with ATP-competitive tyrosine kinase inhibitors. Clinicians now have expanded third-line options, which in most cases will involve a choice between asciminib and ponatinib.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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