Deletion of mouse lysyl oxidase in megakaryocytes affects bone properties in a sex-dependent manner-Reference-Cited by-同舟云学术

Deletion of mouse lysyl oxidase in megakaryocytes affects bone properties in a sex-dependent manner

Published:2024-06-20 Issue:25 Volume:143 Page:2666-2670
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Karagianni Aikaterini¹²^ORCID,Karkempetzaki Anastasia Iris¹²,Brooks Daniel³⁴,Matsuura Shinobu¹^ORCID,Dambal Vrinda⁵^ORCID,Trackman Philip C.⁵⁶,Ravid Katya¹^ORCID

Affiliation:

1. 1Department of Medicine, Whitaker Cardiovascular Research Institute, Boston University Chobanian and Avedisian School of Medicine, Boston, MA

2. 2Department of Internal Medicine, University of Crete, School of Medicine, Heraklion, Greece

3. 3Center for Musculoskeletal Research, Endocrine Unit, Massachusetts General Hospital, Boston, MA

4. 4Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, MA

5. 5Department of Translational Dental Medicine, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA

6. 6Forsyth Institute, Boston, MA

Abstract

Abstract Lysyl oxidase (LOX) is a facilitator of extracellular matrix cross-linking. Using newly developed megakaryocyte-specific LOX knockout mice, we show that LOX expressed in these scarce bone marrow cells affects bone volume and collagen architecture in a sex-dependent manner.

Publisher

American Society of Hematology

Link

https://ashpublications.org/blood/article-pdf/143/25/2666/2230192/blood_bld-2024-024620-main.pdf

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5. Myeloproliferative disorders and their effects on bone homeostasis: the role of megakaryocytes;Karagianni;Blood,2022