Single-cell analysis reveals immune dysfunction from the earliest stages of CLL that can be reversed by ibrutinib

Author:

Purroy Noelia123,Tong Yuzhou Evelyn234,Lemvigh Camilla K.15ORCID,Cieri Nicoletta123ORCID,Li Shuqiang36,Parry Erin M.123ORCID,Zhang Wandi1,Rassenti Laura Z.7,Kipps Thomas J.7,Slager Susan L.8,Kay Neil E.89ORCID,Lesnick Connie9,Shanafelt Tait D.10,Ghia Paolo11ORCID,Scarfò Lydia11,Livak Kenneth J.16ORCID,Kharchenko Peter V.12,Neuberg Donna S.13,Olsen Lars Rønn45ORCID,Fan Jean14ORCID,Gohil Satyen H.12315,Wu Catherine J.12316ORCID

Affiliation:

1. Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA;

2. Harvard Medical School, Boston, MA;

3. Broad Institute, Cambridge, MA;

4. Program in Health Sciences and Technology, Harvard Medical School–Massachusetts Institute of Technology, Boston, MA;

5. Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark;

6. Translational Immunogenomics Laboratory, Dana Farber Cancer Institute, Boston, MA;

7. Moores Cancer Center, University of California San Diego, La Jolla, CA;

8. Department of Health Sciences Research and

9. Department of Medicine, Mayo Clinic, Rochester, MN;

10. Department of Medicine, Stanford University, Stanford, CA;

11. Division of Experimental Oncology, Department of Onco-Hematology, Università Vita-Salute San Raffaele–Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale San Raffaele, Milan Italy;

12. Department of Biomedical Informatics, Harvard Medical School, Boston, MA;

13. Department of Data Science, Dana-Farber Cancer Institute, Boston, MA;

14. Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD;

15. Department of Academic Haematology, University College London, United Kingdom; and

16. Division of Hematology, Department of Medicine, Brigham and Women’s Hospital, Boston, MA

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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