Epigenetic loss of m1A RNA demethylase ALKBH3 in Hodgkin lymphoma targets collagen, conferring poor clinical outcome

Author:

Esteve-Puig Rosaura1ORCID,Climent Fina2,Piñeyro David13ORCID,Domingo-Domènech Eva4ORCID,Davalos Veronica1ORCID,Encuentra Maite4,Rea Anna1ORCID,Espejo-Herrera Nadia2ORCID,Soler Marta1ORCID,Lopez Miguel1ORCID,Ortiz-Barahona Vanessa1,Tapia Gustavo5,Navarro José-Tomás16,Cid Joan7ORCID,Farré Lourdes89ORCID,Villanueva Alberto8,Casanova Isolda11011,Mangues Ramon11011ORCID,Santamarina-Ojeda Pablo12131415ORCID,Fernández Agustín F.12131415ORCID,Fraga Mario F.12131415,Piris Miguel Angel316,Kol Nitzan171819,Avrahami Chen171819ORCID,Moshitch-Moshkovitz Sharon171819ORCID,Rechavi Gideon171819,Sureda Anna4,Esteller Manel132021ORCID

Affiliation:

1. Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Spain;

2. Department of Pathology, Bellvitge Biomedical Research Institute (IDIBELL), Hospital Universitari de Bellvitge, Universitat de Barcelona, L’Hospitalet, Barcelona, Spain;

3. Centro de Investigación Biomédica en Red (CIBER) de Cáncer (CIBERONC), Madrid, Spain;

4. Clinical Hematology Department, Catalan Institute of Oncology (ICO), Hospital Duran i Reynals, L’Hospitalet, Barcelona, Spain;

5. Department of Pathology, Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP) and

6. Department of Hematology, Catalan Institute of Oncology (ICO), Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain;

7. Apheresis and Cellular Therapy Unit, Department of Hemotherapy and Hemostasis (ICMHO), Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, University of Barcelona, Barcelona, Spain;

8. Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain;

9. Laboratory of Experimental Pathology (LAPEX), Gonçalo Moniz Research Center, Oswaldo Cruz Foundation (CPQGM/FIOCRUZ), Salvador, Brazil;

10. CIBER de Bioingeniería Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain;

11. Biomedical Research Institute Sant Pau (IIB-Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain;

12. Nanomaterials and Nanotechnology Research Center–Spanish National Research Council (CINN-CSIC),

13. Health Research Institute of Asturias (ISPA),

14. Institute of Oncology of Asturias (IUOPA), and

15. Department of Organisms and Systems Biology (B.O.S), University of Oviedo, Oviedo, Spain;

16. Service of Pathology, Fundación Jiménez Díaz University Hospital, Madrid, Spain;

17. Cancer Research Center and

18. Wohl Institute for Translational Medicine, Chaim Sheba Medical Center, Tel-Hashomer, Israel;

19. Department of Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel;

20. Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain; and

21. Physiological Sciences Department, School of Medicine and Health Sciences, University of Barcelona (UB), Barcelona, Spain

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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