PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation

Author:

Ren Zhihong12,Ahn Jeong Hyun12ORCID,Liu Hequn3,Tsai Yi-Hsuan1ORCID,Bhanu Natarajan V.4,Koss Brian5,Allison David F.12,Ma Anqi6,Storey Aaron J.5ORCID,Wang Ping3,Mackintosh Samuel G.5,Edmondson Ricky D.5,Groen Richard W. J.7,Martens Anton C.7,Garcia Benjamin A.4,Tackett Alan J.58ORCID,Jin Jian6ORCID,Cai Ling129,Zheng Deyou31011,Wang Gang Greg1212ORCID

Affiliation:

1. Lineberger Comprehensive Cancer Center and

2. Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC;

3. Department of Genetics, Albert Einstein College of Medicine, Bronx, NY;

4. Epigenetics Institute, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA;

5. Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR;

6. Center for Chemical Biology and Drug Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY;

7. Department of Hematology, Amsterdam UMC, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands;

8. Arkansas Children’s Research Institute and UAMS Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR;

9. Department of Genetics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC;

10. Department of Neuroscience and

11. Department of Neurology, Albert Einstein College of Medicine, Bronx, NY; and

12. Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC

Abstract

Abstract Polycomb repressive complex 2 (PRC2) dysregulation is associated with proliferation of hematological malignancies. Ren et al elucidate the mechanisms of PRC2 in multiple myeloma (MM), demonstrating that malignant progression of MM is associated with overexpression of PHF19, a PRC2-associated factor that enhances its gene-regulatory function.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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