Clonal hematopoiesis evolves from pretreatment clones and stabilizes after end of chemotherapy in patients with MCL-Reference-Cited by-同舟云学术

Clonal hematopoiesis evolves from pretreatment clones and stabilizes after end of chemotherapy in patients with MCL

Published:2020-05-28 Issue:22 Volume:135 Page:2000-2004
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Eskelund Christian Winther¹²³^ORCID,Husby Simon¹²³,Favero Francesco²⁴^ORCID,Klausen Tobias Wirenfeldt⁵,Rodriguez-Gonzalez Francisco German²⁴^ORCID,Kolstad Arne⁶,Pedersen Lone Bredo¹,Räty Riikka Katariina⁷,Geisler Christian H.¹,Jerkeman Mats⁸,Weischenfeldt Joachim²⁴^ORCID,Grønbæk Kirsten¹²³^ORCID

Affiliation:

1. Department of Hematology, Rigshospitalet, Copenhagen, Denmark;

2. Biotech Research and Innovation Centre and

3. Danish Stem Cell Center, University of Copenhagen, Copenhagen, Denmark;

4. Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark;

5. Hematological Research Laboratory, Herlev University Hospital, Herlev, Denmark;

6. Department of Oncology, Oslo University Hospital, Oslo, Norway;

7. Department of Hematology, Helsinki University Hospital, Helsinki, Finland; and

8. Department of Oncology, Skåne University Hospital, Lund, Sweden

Abstract

Eskelund et al examined clonal hematopoiesis (CH) in a cohort of patients with mantle cell lymphoma (MCL) treated with first-line chemotherapy and autologous stem cell transplantation. In young, good-risk MCL patients, CH after first-line therapy arises almost entirely from preexisting clones, stabilizes after a period of expansion posttransplantation, and does not negatively impact survival.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/135/22/2000/1736028/bloodbld2019003539.pdf

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