Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism

Author:

Lindström Sara12,Wang Lu3,Smith Erin N.45,Gordon William1,van Hylckama Vlieg Astrid6,de Andrade Mariza7ORCID,Brody Jennifer A.8ORCID,Pattee Jack W.9,Haessler Jeffrey2,Brumpton Ben M.101112ORCID,Chasman Daniel I.1314ORCID,Suchon Pierre1516,Chen Ming-Huei1718,Turman Constance19ORCID,Germain Marine20,Wiggins Kerri L.8ORCID,MacDonald James3ORCID,Braekkan Sigrid K.521,Armasu Sebastian M.7,Pankratz Nathan22,Jackson Rebecca D.23,Nielsen Jonas B.24ORCID,Giulianini Franco13,Puurunen Marja K.18,Ibrahim Manal15,Heckbert Susan R.125,Damrauer Scott M.2627,Natarajan Pradeep28291430ORCID,Klarin Derek283132,de Vries Paul S.33,Sabater-Lleal Maria3435ORCID,Huffman Jennifer E.36ORCID,Bammler Theo K.3,Frazer Kelly A.4537,McCauley Bryan M.7,Taylor Kent38,Pankow James S.39ORCID,Reiner Alexander P.12,Gabrielsen Maiken E.10,Deleuze Jean-François4041,O'Donnell Chris J.171842,Kim Jihye19ORCID,McKnight Barbara243,Kraft Peter19,Hansen John-Bjarne521,Rosendaal Frits R.6ORCID,Heit John A.7ORCID,Psaty Bruce M.2544,Tang Weihong39,Kooperberg Charles2,Hveem Kristian10,Ridker Paul M.1314ORCID,Morange Pierre-Emmanuel151645,Johnson Andrew D.1718,Kabrhel Christopher464748ORCID,Trégouët David-Alexandre20,Smith Nicholas L.12549, ,

Affiliation:

1. Department of Epidemiology, University of Washington, Seattle, WA;

2. Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA;

3. Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA;

4. Department of Pediatrics and Rady Children’s Hospital, University of California San Diego, La Jolla, CA;

5. K.G. Jebsen Thrombosis Research and Expertise Center, Department of Clinical Medicine, UiT–The Arctic University of Norway, Tromsø, Norway;

6. Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands;

7. Department of Health Sciences Research, Mayo Clinic, Rochester, MN;

8. Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA;

9. Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN;

10. K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway;

11. Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom;

12. Clinic of Thoracic and Occupational Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway;

13. Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA;

14. Department of Medicine, Harvard Medical School, Boston, MA;

15. Laboratory of Haematology, La Timone Hospital, Marseille, France;

16. Center for CardioVascular and Nutrition research (C2VN), Universite Aix-Marseille, Institut National de la Recherche Agronomique (INRA), INSERM, Marseille, France;

17. Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, MA;

18. The Framingham Heart Study, Framingham, MA;

19. Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA;

20. INSERM UMR_S 1219, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France;

21. Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway;

22. Department of Laboratory Medicine and Pathology, School of Medicine, University of Minnesota, Minneapolis, MN;

23. Division of Endocrinology, Diabetes, and Metabolism, The Ohio State University, Columbus OH;

24. Division of Cardiology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI;

25. Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA;

26. Department of Surgery, Corporal Michael Crescenz VA Medical Center, Philadelphia, PA;

27. Department of Surgery, Perleman School of Medicine, University of Pennsylvania, Philadelphia, PA;

28. Boston VA Healthcare System, Boston, MA;

29. Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA;

30. Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA;

31. Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA;

32. Department of Surgery, Massachusetts General Hospital, Boston, MA;

33. Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX;

34. Unit of Genomics of Complex Diseases, Institut de Recerca de l’Hospital de Sant Pau, IIB-Sant Pau, Barcelona, Spain;

35. Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden;

36. Center for Population Genomics, MAVERIC, VA Boston Healthcare System, Boston, MA;

37. Institute of Genomic Medicine, University of California San Diego, La Jolla, CA;

38. Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor–University of California Los Angeles Medical Center, Torrence CA;

39. Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN;

40. Centre National de Recherche en Génomique Humaine, Direction de la Recherche Fondamentale, Le Commissariat à l’énergie atomique et aux énergies alternatives, Evry, France;

41. The Centre d’Etude du Polymorphism Humain (CEPH), Fondation Jean Dausset, Paris, France;

42. Million Veteran Program, Veteran's Administration, Boston, MA;

43. Department of Biostatistics, University of Washington, Seattle, WA;

44. Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA;

45. Centre de Ressources Biologiques Assistance Publique–Hôpitaux de Marseille, HemoVasc, Marseille, France;

46. Center for Vascular Emergencies, Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA;

47. Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA;

48. Department of Emergency Medicine, Harvard Medical School, Boston, MA; and

49. Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs Office of Research and Development, Seattle, WA

Abstract

In this work related to familial aggregation of familial venous thromboembolism, the investigators report genomic and transcriptomic association of 16 novel susceptibility loci for venous thromboembolism.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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