Pegylated interferon alfa-2a for polycythemia vera or essential thrombocythemia resistant or intolerant to hydroxyurea

Author:

Yacoub Abdulraheem1ORCID,Mascarenhas John2ORCID,Kosiorek Heidi3,Prchal Josef T.45ORCID,Berenzon Dmitry6,Baer Maria R.7,Ritchie Ellen8ORCID,Silver Richard T.8,Kessler Craig9,Winton Elliott10,Finazzi Maria Chiara11,Rambaldi Alessandro1112ORCID,Vannucchi Alessandro M.1314,Leibowitz David15,Rondelli Damiano16,Arcasoy Murat O.17,Catchatourian Rosalind18,Vadakara Joseph19ORCID,Rosti Vittorio20ORCID,Hexner Elizabeth21ORCID,Kremyanskaya Marina2,Sandy Lonette2,Tripodi Joseph2223ORCID,Najfeld Vesna2223,Farnoud Noushin24,Papaemmanuil Elli252627,Salama Mohamed28,Singer-Weinberg Rona29,Rampal Raajit24,Goldberg Judith D.3031,Barbui Tiziano32,Mesa Ruben33,Dueck Amylou C.3ORCID,Hoffman Ronald2

Affiliation:

1. Division of Hematologic Malignancies and Cellular Therapeutics, The University of Kansas Cancer Center, Westwood, KS;

2. Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY;

3. Mayo Clinic, Scottsdale, AZ;

4. Division of Hematology, University of Utah School of Medicine and

5. Huntsman Cancer Center, Salt Lake City, UT;

6. Comprehensive Cancer Center, Wake Forest University Medical Center, Wake Forest Health, Winston-Salem, NC;

7. Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD;

8. Division of Hematology and Oncology, Department of Medicine, Richard T. Silver Myeloproliferative Neoplasms Center, Weill Cornell Medical College, New York, NY;

9. Georgetown University Medical Center, Washington, DC;

10. Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA;

11. Department of Hematology, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy;

12. Department of Oncology, University of Milan, Ospedale Papa Giovanni XXIII, Bergamo, Italy;

13. Center for Research and Innovation of Myeloproliferative Neoplasms, Azienda Ospedaliero-Universitaria Careggi, and

14. Denothe Excellence Center, University of Florence, Florence, Italy;

15. Department of Oncology, Palo Alto Medical Foundation, Sutter Health, Palo Alto, CA;

16. Division of Hematology and Oncology, University of Illinois, Chicago, IL;

17. Division of Hematology, Duke University School of Medicine, Durham, NC;

18. Department of Oncology, John H. Stroger Jr. Hospital of Cook County, Chicago, IL;

19. Geisinger Medical Center, Danville, PA;

20. Laboratory of Biochemistry, Biotechnology, and Advanced Diagnosis, Center for the Study of Myelofibrosis, Istituto Di Ricovero e Cura a Carattere Scientifico, Foundation Policlinico San Matteo, Pavia, Italy;

21. Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA;

22. Department of Pathology and

23. Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY;

24. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY;

25. Computational Oncology,

26. Center for Hematological Malignancies, and

27. Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY;

28. Mayo Clinic Laboratories, Rochester, MN;

29. New York Blood Center, New York, NY;

30. Department of Population Health and

31. Department of Environmental Medicine, New York University School of Medicine, New York, NY;

32. Ospedali Riuniti, Bergamo, Italy; and

33. UT Health San Antonio Cancer Center, San Antonio, TX

Abstract

Yacoub et al report excellent responses to pegylated interferon alfa-2a in patients with hydroxyurea-resistant/intolerant polycythemia vera or essential thrombocythemia.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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