High efficacy of CD19 CAR T cells in patients with transformed Waldenström macroglobulinemia-Reference-Cited by-同舟云学术

High efficacy of CD19 CAR T cells in patients with transformed Waldenström macroglobulinemia

Published:2024-06-27 Issue:26 Volume:143 Page:2804-2807
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Durot Eric¹^ORCID,Roos-Weil Damien²,Chauchet Adrien³,Decroocq Justine⁴,Di Blasi Roberta⁵^ORCID,Gastinne Thomas⁶,Bensaber Hedi⁷^ORCID,Cheminant Morgane⁸,Jacquet Caroline⁹,Guidez Stéphanie¹⁰,Gros François-Xavier¹¹^ORCID,Bachy Emmanuel¹²^ORCID,Coste Arthur¹^ORCID,Cony-Makhoul Pascale¹³,Treon Steven P.¹⁴^ORCID,Delmer Alain¹^ORCID,Reshef Ran¹⁵,Le Gouill Steven¹⁶^ORCID,Castillo Jorge J.¹⁴^ORCID,Houot Roch¹⁷^ORCID

Affiliation:

1. 1Department of Hematology, University Hospital of Reims, Reims, France

2. 2Sorbonne Université, Hematology, Pitié-Salpêtrière Hospital, Paris, France

3. 3Department of Hematology, University Hospital of Besançon, Besançon, France

4. 4Department of Hematology, Hôpital Cochin, Paris, France

5. 5Department of Hematology, Hôpital Saint Louis, Paris, France

6. 6Department of Hematology, University Hospital of Nantes, Nantes, France

7. 7Department of Hematology, University Hospital of Clermont-Ferrand, Clermont-Ferrand, France

8. 8Department of Hematology, Hôpital Necker, Paris, France

9. 9Department of Hematology, University Hospital of Nancy, Nancy, France

10. 10Department of Hematology, University Hospital of Poitiers, Poitiers, France

11. 11Department of Hematology, University Hospital of de Bordeaux, Bordeaux, France

12. 12Department of Hematology, Hospices Civils de Lyon, Pierre Bénite, Lyon, France

13. 13Medical and Scientific Department, Lymphoma Academic Research Organisation, Hôpital Lyon-Sud, Pierre-Bénite, France

14. 14Bing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

15. 15Division of Hematology/Oncology and Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY

16. 16Department of Hematology, Institut Curie, Paris, France

17. 17Department of Hematology, University Hospital of Rennes, Rennes, France

Abstract

Abstract Histologic transformation of Waldenström macroglobulinemia (HT-WM) carries a poor prognosis with standard treatments. Here, we report the first series of HT-WM treated with chimeric antigen receptor T cells showing a high efficacy and no unexpected toxicity.

Publisher

American Society of Hematology

Link

https://ashpublications.org/blood/article-pdf/143/26/2804/2232809/blood_bld-2024-024452-main.pdf

Reference19 articles.

1. Transformed Waldenström macroglobulinaemia: clinical presentation and outcome: a multi-institutional retrospective study of 77 cases from the French Innovative Leukemia Organization (FILO);Durot;Br J Haematol,2017

2. Impact of MYD88L265P mutation status on histological transformation of Waldenström macroglobulinemia;Zanwar;Am J Hematol,2020

3. Histological transformation to diffuse large B-cell lymphoma in patients with Waldenström macroglobulinemia;Castillo;Am J Hematol,2016

4. A prognostic index predicting survival in transformed Waldenström macroglobulinemia;Durot;Haematologica,2021

5. High frequency of central nervous system involvement in transformed Waldenström macroglobulinemia;Durot;Blood Adv,2022