Endothelial ZIP8 plays a minor role in BMP6 regulation by iron in mice-Reference-Cited by-同舟云学术

Endothelial ZIP8 plays a minor role in BMP6 regulation by iron in mice

Published:2024-06-06 Issue:23 Volume:143 Page:2433-2437
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Fisher Allison L.¹^ORCID,Phillips Sydney¹^ORCID,Wang Chia-Yu¹^ORCID,Paulo Joao A.²^ORCID,Xiao Xia¹^ORCID,Moschetta Gillian A.¹,Sridhar Adhvaith¹,Mancias Joseph D.³,Babitt Jodie L.¹

Affiliation:

1. 1Nephrology Division and Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA

2. 2Department of Cell Biology, Harvard Medical School, Boston, MA

3. 3Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

Abstract

Abstract Iron-mediated induction of bone morphogenetic protein (BMP)6 expression by liver endothelial cells is essential for iron homeostasis regulation. We used multiple dietary and genetic mouse cohorts to demonstrate a minor functional role for the metal-ion transporter ZIP8 in regulating BMP6 expression under high-iron conditions.

Publisher

American Society of Hematology

Link

https://ashpublications.org/blood/article-pdf/143/23/2433/2227987/blood_bld-2023-023385-main.pdf

Reference24 articles.

1. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization;Nemeth;Science,2004

2. Immunoassay for human serum hepcidin;Ganz;Blood,2008

3. Iron homeostasis during pregnancy;Fisher;Am J Clin Nutr,2017

4. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin;Nemeth;J Clin Invest,2004

5. Iron metabolism and iron disorders revisited in the hepcidin era;Camaschella;Haematologica,2020

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