PIKing the right target in AML
Author:
Affiliation:
1. Roswell Park Comprehensive Cancer Center
Publisher
American Society of Hematology
Link
https://ashpublications.org/blood/article-pdf/143/19/1884/2224751/blood_bld-2024-024035-c-main.pdf
Reference9 articles.
1. PI3Kγ maintains the self-renewal of acute myeloid leukemia stem cells by regulating the pentose phosphate pathway;Gu;Blood,2024
2. Constitutive phosphoinositide 3-kinase/Akt activation represents a favorable prognostic factor in de novo acute myelogenous leukemia patients;Tamburini;Blood,2007
3. Survival of acute myeloid leukemia cells requires PI3 kinase activation;Xu;Blood,2003
4. Single-cell pharmacodynamic monitoring of S6 ribosomal protein phosphorylation in AML blasts during a clinical trial combining the mTOR inhibitor sirolimus and intensive chemotherapy;Perl;Clin Cancer Res,2012
5. Targeting epigenetic resistance mechanisms to PI3 kinase inhibition in leukemic stem cells;Glushakow-Smith;Blood,2023
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