IL-7R is essential for leukemia-initiating cell activity of T-cell acute lymphoblastic leukemia-Reference-Cited by-同舟云学术

IL-7R is essential for leukemia-initiating cell activity of T-cell acute lymphoblastic leukemia

Published:2019-12-12 Issue:24 Volume:134 Page:2171-2182
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

González-García Sara¹^ORCID,Mosquera Marta¹,Fuentes Patricia¹^ORCID,Palumbo Tiziana¹,Escudero Adela²^ORCID,Pérez-Martínez Antonio²³⁴^ORCID,Ramírez Manuel⁵^ORCID,Corcoran Anne E.⁶^ORCID,Toribio Maria L.¹^ORCID

Affiliation:

1. Department of Cell Biology and Immunology, Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), Madrid, Spain;

2. Translational Research in Pediatric Oncology, Hematopoietic Transplantation and Cell Therapy, Instituto de Genética Médica y Molecular del Instituto de Investigación Sanitaria del Hospital Universitario La Paz (INGEMM-IdiPAZ), Madrid, Spain;

3. Pediatric Hemato-Oncology Service, Hospital Universitario La Paz, Madrid, Spain;

4. Department of Pediatrics, UAM, Madrid, Spain;

5. Department of Pediatric Hematology and Oncology, Hospital Infantil Universitario Niño Jesús, UAM, Spain and

6. Nuclear Dynamics Programme and Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom

Abstract

Key Points IL-7R expression is a functional biomarker of T-ALL cells with leukemia-initiating potential and plays a crucial role in T-ALL pathogenesis. Targeting IL-7R–mediated signaling hampers leukemia-initiating activity and progression of human T-ALL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/134/24/2171/1547443/bloodbld2019000982.pdf

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