Platelet lamellipodium formation is not required for thrombus formation and stability-Reference-Cited by-同舟云学术

Platelet lamellipodium formation is not required for thrombus formation and stability

Published:2019-12-19 Issue:25 Volume:134 Page:2318-2329
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Schurr Yvonne¹²,Sperr Andreas¹²,Volz Julia¹²,Beck Sarah¹²,Reil Lucy¹²,Kusch Charly¹²,Eiring Patrick³,Bryson Sheila⁴^ORCID,Sauer Markus³,Nieswandt Bernhard¹²^ORCID,Machesky Laura⁴⁵^ORCID,Bender Markus¹²^ORCID

Affiliation:

1. Institute of Experimental Biomedicine–Chair I, University Hospital,

2. Rudolf Virchow Center, and

3. Department of Biotechnology and Biophysics, Biocenter, Julius Maximilian University of Würzburg, Würzburg, Germany;

4. Beatson Institute, Cancer Research UK, Glasgow, United Kingdom; and

5. Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

Abstract

Key Points Cyfip1 plays a crucial role for branching of actin filaments and for lamellipodium formation. Lamellipodium formation is not required for the formation of a hemostatic plug or thrombus.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/134/25/2318/1549342/bloodbld2019002105r1.pdf

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4. Mechanisms of actin rearrangements mediating platelet activation;Hartwig;J Cell Biol,1992

5. Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow;McCarty;J Biol Chem,2005

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