IL-6 dysregulation originates in dendritic cells and mediates graft-versus-host disease via classical signaling-Reference-Cited by-同舟云学术

IL-6 dysregulation originates in dendritic cells and mediates graft-versus-host disease via classical signaling

Published:2019-12-05 Issue:23 Volume:134 Page:2092-2106
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Wilkinson Andrew N.¹²^ORCID,Chang Karshing¹,Kuns Rachel D.¹,Henden Andrea S.¹²³^ORCID,Minnie Simone A.¹²,Ensbey Kathleen S.¹,Clouston Andrew D.⁴,Zhang Ping¹^ORCID,Koyama Motoko¹⁵,Hidalgo Juan⁶⁷^ORCID,Rose-John Stefan⁸^ORCID,Varelias Antiopi¹²^ORCID,Vuckovic Slavica¹²,Gartlan Kate H.¹²⁵^ORCID,Hill Geoffrey R.¹³⁵⁹

Affiliation:

1. QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia;

2. Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia;

3. Royal Brisbane and Women’s Hospital, Brisbane, QLD, Australia;

4. Envoi Specialist Pathologists, Brisbane, QLD, Australia;

5. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA;

6. Animal Physiology Unit, Department of Cellular Biology, Physiology and Immunology, Faculty of Biosciences, and

7. Institute of Neurosciences, Universitat Autònoma de Barcelona, Bellaterra, Spain;

8. Institute of Biochemistry, Christian-Albrechts-Universität zu Kiel, Kiel, Germany; and

9. Division of Medical Oncology, University of Washington, Seattle, WA

Abstract

Key Points DCs are the principal source of IL-6 dysregulation after alloSCT. IL-6–dependent GVHD is driven by classical signaling of IL-6R on donor T cells but is regulated by trans signaling.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/134/23/2092/1545370/bloodbld2019000396.pdf

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