The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance-Reference-Cited by-同舟云学术

The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance

Published:2019-08-21 Issue:14 Volume:134 Page:1154-1158
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Agger Karl¹²,Nishimura Koutarou¹²³⁴,Miyagi Satoru¹,Messling Jan-Erik¹²,Rasmussen Kasper Dindler¹²,Helin Kristian¹²³⁴^ORCID

Affiliation:

1. Biotech Research and Innovation Centre and

2. The Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, Copenhagen, Denmark; and

3. Cell Biology Program and

4. Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY

Abstract

Abstract KDM4 and JMJD2 are histone demethylases that are considered promising targets for treatment of MLL translocation–bearing acute myeloid leukemia. Agger and colleagues demonstrate an important role of KDM4 activity in long-term normal hematopoiesis that should be considered when contemplating the clinical use of long-term inhibition of KDM4 demethylase activity.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/134/14/1154/1223029/bloodbld2019000855.pdf

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