Terminal deoxynucleotidyl transferase promotes acute myeloid leukemia by priming FLT3-ITD replication slippage-Reference-Cited by-同舟云学术

Terminal deoxynucleotidyl transferase promotes acute myeloid leukemia by priming FLT3-ITD replication slippage

Published:2019-12-19 Issue:25 Volume:134 Page:2281-2290
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Borrow Julian¹²,Dyer Sara A.¹²,Akiki Susanna¹³,Griffiths Michael J.¹²^ORCID

Affiliation:

1. West Midlands Regional Genetics Laboratory, Birmingham Women’s and Children’s NHS Foundation Trust, Birmingham, United Kingdom;

2. Institute of Cancer and Genomic Studies, University of Birmingham, Birmingham, United Kingdom; and

3. Diagnostic Genomic Division, Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar

Abstract

These complementary papers by Borrow et al report persuasive but indirect evidence that the lymphoid enzyme terminal deoxynucleotidyl transferase (TdT) is the mutagen responsible for 2 common pathogenic genetic changes in acute myeloid leukemia (AML): FLT3-ITD and NPM1.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/134/25/2281/1549285/bloodbld2019001238.pdf

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