Primary cytotoxic T-cell lymphomas harbor recurrent targetable alterations in the JAK-STAT pathway-Reference-Cited by-同舟云学术

Primary cytotoxic T-cell lymphomas harbor recurrent targetable alterations in the JAK-STAT pathway

Published:2021-12-09 Issue:23 Volume:138 Page:2435-2440
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Lee Katie¹²^ORCID,Evans Mark G.³^ORCID,Yang Lei⁴,Ng Spencer¹^ORCID,Snowden Caroline¹²,Khodadoust Michael⁵¹^ORCID,Brown Ryanne A.¹⁶^ORCID,Trum Nicholas A.⁷^ORCID,Querfeld Christiane⁷^ORCID,Doan Linda T.⁸,Song Jinming⁹,Zhang Hailing⁹,Gru Alejandro A.¹⁰,Wood Gary S.¹¹,Wada David A.¹¹²,Shanmugam Vignesh³,Haun Paul L.¹³,Aster Jon C.³,Duncan Lyn M.¹⁴,Guitart Joan¹,Weinstock David M.⁴^ORCID,Nardi Valentina¹⁴,Choi Jaehyuk¹²¹⁵¹⁶^ORCID

Affiliation:

1. Department of Dermatology and

2. Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL;

3. Department of Pathology, Brigham and Women’s Hospital and

4. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;

5. Division of Oncology, Department of Medicine

6. Department of Pathology, Stanford University School of Medicine, Stanford, CA;

7. Department of Dermatology, City of Hope National Medical Center, Duarte, CA;

8. Department of Dermatology, University of California, Irvine, Irvine, CA;

9. Department of Pathology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL;

10. Department of Pathology, University of Virginia, Charlottesville, VA;

11. Department of Dermatology, University of Wisconsin, Madison, WI;

12. Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, UT;

13. Penn Cutaneous Lymphoma Program, Department of Dermatology, Perelman Center for Advanced Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA;

14. Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA;

15. Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL; and

16. Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL

Abstract

Primary cytotoxic T cell lymphomas (CTCLs) are a rare subset of aggressive, poor-prognosis T-cell lymphomas targeting the skin; they include primary cutaneous γδT-cell lymphoma, primary cutaneous VD8+ aggressive epidermotropic T cell lymphoma (PCAETCL), and cytotoxic CTCL not otherwise specified. Lee et al report that all 3 subsets have JAK-STAT activation, but PCAETCL uniquely carries JAK2 gene fusions that may render them especially susceptible to JAK inhibitors.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

https://ashpublications.org/blood/article-pdf/138/23/2435/1850373/bloodbld2021012536.pdf

Reference19 articles.

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3. Primary cutaneous aggressive epidermotropic cytotoxic T-cell lymphomas: reappraisal of a provisional entity in the 2016 WHO classification of cutaneous lymphomas;Guitart;Mod Pathol.,2017

4. Gamma-delta T-cell phenotype is associated with significantly decreased survival in cutaneous T-cell lymphoma;Toro;Blood.,2003

5. Cellular origins and genetic landscape of cutaneous gamma delta T cell lymphomas;Daniels;Nat Commun.,2020

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