Vaccine-induced immune thrombotic thrombocytopenia-Reference-Cited by-同舟云学术

Vaccine-induced immune thrombotic thrombocytopenia

Published:2023-04-06 Issue:14 Volume:141 Page:1659-1665
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Cines Douglas B.¹^ORCID,Greinacher Andreas²^ORCID

Affiliation:

1. 1Departments of Pathology and Laboratory Medicine and Medicine, Perelman-University of Pennsylvania School of Medicine, Philadelphia, PA

2. 2Institut für Transfusionsmedizin, Universitätsmedizin Greifswald, Greifswald, Germany

Abstract

Abstract Within the first months of the COVID-19 vaccination campaign, previously healthy recipients who developed severe thrombosis (often cerebral and/or splanchnic vasculature) and thrombocytopenia typically after adenoviral vector-based vaccination were identified. Similarities between this syndrome, vaccine-induced immune thrombotic thrombocytopenia (VITT), and heparin-induced thrombocytopenia prompted recognition of the role of antiplatelet factor 4 (PF4) antibodies and management strategies based on IV immunoglobulin and nonheparin anticoagulants, which improved outcome. We update current understanding of VITT and potential involvement of anti-PF4 antibodies in thrombotic disorders.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

https://ashpublications.org/blood/article-pdf/141/14/1659/2087497/blood_bld-2022-017696-c-main.pdf

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