Identifying <i>STRN3-RARA</i> as a new fusion gene for acute promyelocytic leukemia-Reference-Cited by-同舟云学术

Identifying STRN3-RARA as a new fusion gene for acute promyelocytic leukemia

Published:2023-10-26 Issue:17 Volume:142 Page:1494-1499
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Zhang Qi¹,Li He²,Chen Xuelan¹^ORCID,Gu Fan¹,Zhang Lanxin¹,Zhang Lu¹^ORCID,Chen Tong³,Chen Qiang⁴,Meng Wentong⁵^ORCID,Wu Yu²^ORCID,Chang Hong²,Liu Ting²^ORCID,Chen Chong¹,Ma Hongbing²^ORCID,Liu Yu¹^ORCID

Affiliation:

1. 1Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China

2. 2Department of Hematology, Institute of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan, China

3. 3Sichuan Hua Xi Kindstar Medical Diagnostic Centre, Chengdu, Sichuan, China

4. 4Sichuan Neo-Life Stem Cell Biotech Inc, Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, Sichuan, China

5. 5Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China

Abstract

Abstract Here we report a new fusion gene, STRN3-RARA, in acute promyelocytic leukemia (APL). It cooperates with UTX deficiency to drive full-blown APL in mice. Although STRN3-RARA leukemia quickly relapses after all-trans retinoic acid treatment, it can be restrained by cepharanthine.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

https://ashpublications.org/blood/article-pdf/142/17/1494/2085605/blood_bld-2023-020619-main.pdf

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