Extracellular RNA released due to shear stress controls natural bypass growth by mediating mechanotransduction in mice

Author:

Lasch Manuel12,Kleinert Eike Christian1,Meister Sarah34,Kumaraswami Konda1,Buchheim Judith-Irina15,Grantzow Tobias1,Lautz Thomas1,Salpisti Sofia6,Fischer Silvia6,Troidl Kerstin78,Fleming Ingrid9,Randi Anna M.10,Sperandio Markus1ORCID,Preissner Klaus T.6,Deindl Elisabeth1

Affiliation:

1. Walter Brendel Centre of Experimental Medicine, University Hospital,

2. Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital,

3. Institut für Laboratoriumsmedizin,

4. Department of Obstetrics and Gynaecology, and

5. Laboratory of Translational Research “Stress and Immunity,” Department of Anaesthesiology, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany;

6. Institute for Biochemistry, Medical School, Justus-Liebig-Universität, Giessen, Germany;

7. Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany;

8. Department of Vascular and Endovascular Surgery, University Hospital Frankfurt, Frankfurt am Main, Germany;

9. Institute for Vascular Signalling, Vascular Research Centre, Goethe University, Frankfurt am Main, Germany; and

10. National Heart and Lung Institute, Hammersmith Hospital, Imperial College London, London, United Kingdom

Abstract

Key PointsShear stress–induced release of RNA from endothelial cells is crucial for initiation of arteriogenesis by controlling mechanotransduction. Extracellular RNA is essential for VWF release from endothelial cells initiating the inflammatory process driving arteriogenesis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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