Lactate administration improves laboratory parameters in murine models of iron overload-Reference-Cited by-同舟云学术

Lactate administration improves laboratory parameters in murine models of iron overload

Published:2024-03-14 Issue:11 Volume:143 Page:1045-1049
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Liu Wei¹²^ORCID,Wu Yue²³^ORCID,Wei Huaiqing¹⁴^ORCID,Ma Juan²³^ORCID,Feng Wenya²³,Yang Qiuyuan²³,Zhang Shuping¹⁴^ORCID,Ganz Tomas⁵^ORCID,Liu Sijin¹²³^ORCID

Affiliation:

1. 1Medical Science and Technology Innovation Center, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China

2. 2State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China

3. 3University of Chinese Academy of Sciences, Beijing, China

4. 4Biomedical Sciences College and Shandong Medicinal Biotechnology Centre, NHC Key Laboratory of Biotechnology Drugs (Shandong Academy of Medical Sciences), Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China

5. 5Department of Medicine, Center for Iron Disorders, David Geffen School of Medicine, University of California, Los Angeles, CA

Abstract

Abstract Current iron overload therapeutics have inherent drawbacks including perpetuated low hepcidin. Here, we unveiled that lactate, a potent hepcidin agonist, effectively reduced serum and hepatic iron levels in mouse models of iron overload with an improved erythropoiesis in β-thalassemic mice.

Publisher

American Society of Hematology

Link

https://ashpublications.org/blood/article-pdf/143/11/1045/2218065/blood_bld-2023-021695-main.pdf

Reference6 articles.

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3. Iron overload in human disease;Fleming;N Engl J Med,2012

4. Hepcidin: a promising therapeutic target for iron disorders: a systematic review;Liu;Medicine (Baltimore),2016

5. New thiazolidinones reduce iron overload in mouse models of hereditary hemochromatosis and beta-thalassemia;Liu;Haematologica,2019

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