Are apixaban and rivaroxaban distributed into human breast milk to clinically relevant concentrations?

Author:

Zhao Yating123ORCID,Arya Roopen2ORCID,Couchman Lewis3ORCID,Patel Jignesh P.12ORCID

Affiliation:

1. Institute of Pharmaceutical Science, King’s College London, London, United Kingdom;

2. King’s Thrombosis Centre, Department of Haematological Medicine, King’s College Hospital National Health Service Foundation Trust, London, United Kingdom; and

3. Analytical Services International Ltd, London, United Kingdom

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference20 articles.

1. Royal College of Obstetricians and Gynaecologists . Thrombosis and embolism during pregnancy and the puerperium, reducing the risk (Green-top Guideline No. 37a). https://www.rcog.org.uk/en/guidelines-research-services/guidelines/gtg37a/. Updated 2015. Accessed 27 March 2020.

2. Guidance for the treatment and prevention of obstetric-associated venous thromboembolism;Bates;J Thromb Thrombolysis,2016

3. Women’s views on and adherence to low-molecular-weight heparin therapy during pregnancy and the puerperium;Patel;J Thromb Haemost,2012

4. Tissue distribution and elimination of [14C]apixaban in rats;Wang;Drug Metab Dispos,2011

5. The direct factor Xa inhibitor rivaroxaban passes into human breast milk;Wiesen;Chest,2016

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2. Direct oral anticoagulants for treatment of venous thrombosis: illustrated review of appropriate use;Research and Practice in Thrombosis and Haemostasis;2024-05

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