Salt-inducible kinase inhibition suppresses acute myeloid leukemia progression in vivo-Reference-Cited by-同舟云学术

Salt-inducible kinase inhibition suppresses acute myeloid leukemia progression in vivo

Published:2020-01-02 Issue:1 Volume:135 Page:56-70
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Tarumoto Yusuke¹²^ORCID,Lin Shan³⁴,Wang Jinhua⁵⁶,Milazzo Joseph P.¹,Xu Yali¹,Lu Bin¹,Yang Zhaolin¹^ORCID,Wei Yiliang¹^ORCID,Polyanskaya Sofya¹⁷^ORCID,Wunderlich Mark⁸^ORCID,Gray Nathanael S.⁵⁶^ORCID,Stegmaier Kimberly³⁴,Vakoc Christopher R.¹^ORCID

Affiliation:

1. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY;

2. Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan;

3. Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston Children’s Hospital, Boston, MA;

4. Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA;

5. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA;

6. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA;

7. Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY; and

8. Division of Experimental Hematology and Cancer Biology, Cancer and Blood Disease Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH

Abstract

Transcription factors are important drivers in acute myeloid leukemia (AML), but they are notoriously difficult to target. The authors demonstrate that inhibition of salt-inducible kinase (SIK3) inhibits AML cell proliferation in cells dependent on the transcription factor MEF2C, identifying a small molecule that can disrupt a leukemogenic transcription factor pathway.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/135/1/56/1550441/bloodbld2019001576.pdf

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