Activated stromal cells transfer mitochondria to rescue acute lymphoblastic leukemia cells from oxidative stress-Reference-Cited by-同舟云学术

Activated stromal cells transfer mitochondria to rescue acute lymphoblastic leukemia cells from oxidative stress

Published:2019-09-09 Issue:17 Volume:134 Page:1415-1429
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Burt Richard¹,Dey Aditi¹,Aref Sarah¹,Aguiar Melanie¹,Akarca Ayse²,Bailey Katharine¹,Day William¹,Hooper Steven³,Kirkwood Amy⁴,Kirschner Kristina⁵^ORCID,Lee Soo-Wah¹,Lo Celso Cristina³⁶,Manji Jiten¹,Mansour Marc R.¹,Marafioti Teresa²,Mitchell Rachel J.¹,Muirhead Robert C.¹,Cheuk Yan Ng Kenton¹,Pospori Constandina³⁶,Puccio Ignazio¹^ORCID,Zuborne-Alapi Krisztina¹,Sahai Erik³,Fielding Adele K.¹

Affiliation:

1. Department of Haematology and

2. Department of Cellular Pathology, UCL Cancer Institute, London, United Kingdom;

3. The Sir Francis Crick Institute, London, United Kingdom;

4. Cancer Research UK and UCL Cancer Trials Centre, London, United Kingdom;

5. Institute for Cancer Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom; and

6. Department of Life Sciences, Imperial College London, London, United Kingdom

Abstract

Key Points MSCs can become cancer-associated fibroblasts and transfer mitochondria to rescue B-ALL cells from ROS-inducing chemotherapy. Rescue of B-ALL cells is overcome by microtubule inhibitors, which interrupt the tunneling nanotubes used for mitochondrial transfer.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/134/17/1415/1502485/bloodbld2019001398.pdf

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