A potential mechanism for the cytoprotective effects of activated protein C–released endothelial extracellular vesicles-Reference-Cited by-同舟云学术

A potential mechanism for the cytoprotective effects of activated protein C–released endothelial extracellular vesicles

Published:2024-04-18 Issue:16 Volume:143 Page:1670-1675
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Das Kaushik¹^ORCID,Keshava Shiva¹^ORCID,Mukherjee Tanmoy¹^ORCID,Rao L. Vijaya Mohan¹^ORCID

Affiliation:

1. Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX

Abstract

Abstract Activated protein C (APC) was shown to release extracellular vesicles (EVs). APC bound to the EVs was thought to be responsible for cytoprotection. Our study demonstrates that the cytoprotective effects of APC-released EVs are independent of APC. APC-released EVs carry anti-inflammatory microRNAs in their cargo.

Publisher

American Society of Hematology

Link

https://ashpublications.org/blood/article-pdf/143/16/1670/2222285/blood_bld-2023-023518-main.pdf

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