Co-occurrence of DNMT3A, NPM1, FLT3 mutations identifies a subset of acute myeloid leukemia with adverse prognosis

Author:

Bezerra Matheus F.12,Lima Aleide S.3,Piqué-Borràs Maria-Riera4,Silveira Douglas R.56ORCID,Coelho-Silva Juan L.37ORCID,Pereira-Martins Diego A.37ORCID,Weinhäuser Isabel7,Franca-Neto Pedro L.3ORCID,Quek Lynn89,Corby Anna9,Oliveira Mayara M.3,Lima Marinus M.3,de Assis Reijane A.10,de Melo Campos Paula11,Duarte Bruno K.1112ORCID,Bendit Israel5ORCID,Rocha Vanderson5,Rego Eduardo M.5ORCID,Traina Fabiola7,Saad Sara T.1112,Beltrão Eduardo I.13,Bezerra Marcos A.3,Lucena-Araujo Antonio R.3ORCID

Affiliation:

1. Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife, Brazil;

2. Aggeu Magalhães Institute, Oswaldo Cruz Foundation, Recife, Brazil;

3. Department of Genetics, Federal University of Pernambuco, Recife, Brazil;

4. Department of Biomedicine, University of Basel, Basel, Switzerland;

5. Hematology Division, LIM31, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil;

6. Hematology Department, AC Camargo Cancer Center, São Paulo, Brazil;

7. Department of Internal Medicine, Medical School of Ribeirão Preto, Ribeirão Preto, Brazil;

8. Department of Hematology, Oxford University Hospitals National Health Service (NHS) Foundation Trust, Oxford, United Kingdom;

9. Medical Research Council (MRC) Molecular Hematology Unit, Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, United Kingdom;

10. Department of Internal Medicine, Hematology and Hemotherapy Foundation of Pernambuco, Recife, Brazil;

11. Hematology and Transfusion Medicine Center and

12. Department of Internal Medicine, University of Campinas, Campinas, São Paulo, Brazil; and

13. Department of Biochemistry, Federal University of Pernambuco, Recife, Brazil

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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