The BTK inhibitor ibrutinib may protect against pulmonary injury in COVID-19–infected patients

Author:

Treon Steven P.12ORCID,Castillo Jorge J.12ORCID,Skarbnik Alan P.3,Soumerai Jacob D.24,Ghobrial Irene M.12,Guerrera Maria Luisa12,Meid Kirsten1,Yang Guang12ORCID

Affiliation:

1. Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Boston, MA;

2. Department of Medicine, Harvard Medical School, Boston, MA;

3. Lymphoproliferative Disorders Program, Novant Health, Charlotte, NC; and

4. Massachusetts General Hospital, Boston, MA

Abstract

Treon et al provide early clinical data supporting a theoretical rationale for continuing ibrutinib in patients receiving the drug during COVID-19 illness.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference25 articles.

1. Inhibiting Bruton’s tyrosine kinase rescues mice from lethal influenza-induced acute lung injury;Florence;Am J Physiol Lung Cell Mol Physiol,2018

2. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China;Wang;JAMA,2020

3. Covid-19 in critically ill patients in the Seattle region - case series [published online ahead of print 30 March 2020];Bhatraju;N Engl J Med

4. A trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19 [published online ahead of print 30 March 2020];Cao;N Engl J Med

5. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China [published online ahead of print 13 March 2020];Wu;JAMA Intern Med

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