Chromatin occupancy and epigenetic analysis reveal new insights into the function of the GATA1 N terminus in erythropoiesis-Reference-Cited by-同舟云学术

Chromatin occupancy and epigenetic analysis reveal new insights into the function of the GATA1 N terminus in erythropoiesis

Published:2019-08-13 Issue:19 Volume:134 Page:1619-1631
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Ling Te¹,Birger Yehudit²³⁴,Stankiewicz Monika J.¹,Ben-Haim Nissim⁵,Kalisky Tomer⁵^ORCID,Rein Avigail²³⁴,Kugler Eitan²³⁴,Chen Wei¹,Fu Chunling⁶,Zhang Kevin¹,Patel Hiral¹,Sikora Jacek W.⁷^ORCID,Goo Young Ah⁷,Kelleher Neil⁸^ORCID,Zou Lihua⁹,Izraeli Shai²³⁴,Crispino John D.¹⁹

Affiliation:

1. Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL;

2. The Gene Development and Environment Pediatric Research Institute, Pediatric Hemato-Oncology, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel;

3. Department of Human Molecular Genetics and Biochemistry, Sackler Medical School, Tel Aviv University, Tel Aviv, Israel;

4. Division of Pediatric Hematology and Oncology, Schneider Children’s Medical Center of Israel, Petach Tikva, Israel;

5. Faculty of Engineering and Institute for Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan, Israel;

6. Blood Disease Institute, Xuzhou Medical University, Xuzhou, China;

7. Proteomics Center of Excellence, Northwestern University, Chicago, IL;

8. Department of Chemistry and Molecular Biosciences and Proteomics Center of Excellence, Northwestern University, Evanston, IL; and

9. Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL

Abstract

GATA1 has a foundational role in erythropoiesis. The investigators compare the function of 2 forms (the full-length protein and a shorter form) of the transcription factor GATA1 and show that the N-terminal domain of GATA1 is critical to red cell differentiation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/134/19/1619/1505409/bloodbld2019001234.pdf

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