Human ApoE Isoforms Differentially Modulate Glucose and Amyloid Metabolic Pathways in Female Brain: Evidence of the Mechanism of Neuroprotection by ApoE2 and Implications for Alzheimer’s Disease Prevention and Early Intervention

Author:

Keeney Jeriel Thomas-Richard1,Ibrahimi Shaher1,Zhao Liqin12

Affiliation:

1. Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS, USA

2. Neuroscience Graduate Program, University of Kansas, Lawrence, KS, USA

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

Reference99 articles.

1. Alzheimer’s disease: The challenge of the second century;Holtzman;Sci Transl Med,2011

2. 2013 Alzheimer’s disease facts and figures;Thies;Alzheimers Dement,2013

3. Alzheimer’s Disease Education & Referral Center (National Institute on Aging) (2008) Alzheimer’s disease fact sheet, Alzheimer’s Disease Education & Referral (ADEAR) Center, Silver Spring, MD

4. Sting of Alzheimer’s failures offset by upcoming prevention trials;Mullard;Nat Rev Drug Discov,2012

5. Brain glucose metabolism in the early and specific diagnosis of Alzheimer’s disease. FDG-PET studies in MCI and AD;Mosconi;Eur J Nucl Med Mol Imaging,2005

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