Metformin Improves Learning and Memory in the SAMP8 Mouse Model of Alzheimer’s Disease

Author:

Farr Susan A.12,Roesler Elizabeth2,Niehoff Michael L.2,Roby Deborah A.3,McKee Alexis4,Morley John E.2

Affiliation:

1. Research and Development Service, VA Medical Center, MO, USA

2. Division of Geriatric Medicine, Saint Louis University School of Medicine, MO, USA

3. Department of Pharmacology and Physiology, Saint Louis University School of Medicine, MO, USA

4. Division of Endocrinology, Diabetes, and Metabolism, Saint Louis University, MO, USA

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

Reference57 articles.

1. Alzheimer’s disease: Past, present, and future;Bondi;J Int Neuropsychol Soc,2017

2. Defective insulin signalling, mediated by inflammation, connects obesity to Alzheimer disease; Relevant pharmacological therapies and preventive dietary interventions;Rodriguez-Casado;Curr Alzheimer Res,2017

3. Repurposing diabetes drugs for brain insulin resistance in Alzheimer disease;Yarchoan;Diabetes,2014

4. Incidence of dementia is increased in type 2 diabetes and reduced by the use of sulfonylureas and metformin;Hsu;J Alzheimers Dis,2011

5. Antidiabetic drugs and their potential role in treating mild cognitive impairment and Alzheimer’s disease;Alagiakrishnan;Discov Med,2013

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