Unique Sleep and Circadian Rhythm Dysfunction Neuroinflammatory and Immune Profiles in Alzheimer’s Disease with Mild Cognitive Impairment-Reference-Cited by-同舟云学术

Unique Sleep and Circadian Rhythm Dysfunction Neuroinflammatory and Immune Profiles in Alzheimer’s Disease with Mild Cognitive Impairment

Published:2021-05-18 Issue:2 Volume:81 Page:487-492
ISSN:1387-2877
Container-title:Journal of Alzheimer's Disease
language:
Short-container-title:JAD

Author:

Pillai Jagan A.¹²³,Bena James⁴,Bekris Lynn M.⁵,Foldvary-Schaefer Nancy⁶,Heinzinger Catherine⁶,Rao Sujata⁷⁸,Rao Stephen M.¹²,Leverenz James B.¹²³,Mehra Reena⁶⁹¹⁰¹¹

Affiliation:

1. Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, OH, USA

2. Neurological Institute, Cleveland Clinic, Cleveland, OH, USA

3. Department of Neurology, Cleveland Clinic, Cleveland, OH, USA

4. Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA

5. Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH, USA

6. Sleep Disorders Center, Neurologic Institute, Cleveland Clinic, Cleveland, OH, USA

7. Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA

8. Department of Ophthalmology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA

9. Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA

10. Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA

11. Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA

Abstract

Sleep dysfunction has been identified in the pathophysiology of Alzheimer’s disease (AD); however, the role and mechanism of circadian rhythm dysfunction is less well understood. In a well-characterized cohort of patients with AD at the mild cognitive impairment stage (MCI-AD), we identify that circadian rhythm irregularities were accompanied by altered humoral immune responses detected in both the cerebrospinal fluid and plasma as well as alterations of cerebrospinal fluid biomarkers of neurodegeneration. On the other hand, sleep disruption was more so associated with abnormalities in circulating markers of immunity and inflammation and decrements in cognition.

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

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