Ventricular Electrocardiographic Signatures Associated with Dementia and Plasma Alzheimer’s Disease Biomarkers in Older Adults: A Population-Based Study
-
Published:2023-08-15
Issue:4
Volume:94
Page:1515-1526
-
ISSN:1387-2877
-
Container-title:Journal of Alzheimer's Disease
-
language:
-
Short-container-title:JAD
Author:
Mao Ming1, Wang Chaoqun1, Hou Tingting2, Han Xiaolei2, Liu Rui1, Han Qi1, Dong Yi2, Wang Jiafeng1, Liu Cuicui2, Cong Lin2, Imahori Yume3, Vetrano Davide Liborio34, Wang Yongxiang23, Du Yifeng12, Qiu Chengxuan13
Affiliation:
1. Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China 2. Department of Neurology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, China 3. Aging Research Center and Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet-Stockholm University, Stockholm, Sweden 4. Stockholm Gerontology Research Center, Stockholm, Sweden
Abstract
Background: Evidence has emerged that altered ventricular electrocardiogram profiles are associated with dementia, but the neuropathological mechanisms underlying their associations are poorly understood. Objective: To investigate the interrelationships of ventricular electrocardiogram profiles with dementia and plasma Alzheimer’s disease (AD) biomarkers among older adults. Methods: This population-based cross-sectional study included 5,153 participants (age ≥65 years; 57.3% women) living in rural communities in China; of these, 1,281 had data on plasma amyloid-β (Aβ)40, Aβ42, total-tau, and neurofilament light chain (NfL) protein. The QT, QTc, JT, JTc, QRS intervals, and QRS axis were derived from the 10-second electrocardiogram recording. The DSM-IV criteria were followed for clinical diagnosis of dementia, the NIA-AA criteria for AD, and the NINDS-AIREN criteria for vascular dementia (VaD). Data were analyzed using general linear models, multinomial logistic models, and restricted cubic splines. Results: Of the 5,153 participants, 299 (5.8%) were diagnosed with dementia, including 194 with AD and 94 with VaD. Prolonged QT, QTc, JT, and JTc intervals were significantly associated with all-cause dementia, AD, and VaD (p < 0.05). Left QRS axis deviation was significantly associated with all-cause dementia and VaD (p < 0.01). In the subsample of plasma biomarkers (n = 1,281), prolonged QT, JT, and JTc intervals were significantly associated with a lower Aβ42/Aβ40 ratio and higher plasma NfL concentrations (p < 0.05). Conclusion: Alterations in ventricular repolarization and depolarization are independently associated with all-cause dementia, AD, VaD, and AD plasma biomarkers in older adults (age ≥65 years). Ventricular electrocardiogram parameters may be valuable clinical markers for dementia and the underlying AD pathologies and neurodegeneration.
Subject
Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience
Reference45 articles.
1. Gauthier S , Rosa-Neto P , Morais JA , Webster C (2021) World Alzheimer Report 2021. Journey through the diagnosis of dementia. Alzheimer’s Disease International, UK, London. 2. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission;Livingston;Lancet,2020 3. A major role for cardiovascular burden in age-related cognitive decline;Qiu;Nat Rev Cardiol,2015 4. Mixed brain lesions mediate the association between cardiovascular risk burden and cognitive decline inold age: A population-based study;Wang;Alzheimers Dement,2017 5. Coronary heart disease, heart failure, and the risk of dementia: A systematic review and meta-analysis;Wolters;Alzheimers Dement,2018
|
|