T Lymphocytes in Parkinson’s Disease-Reference-Cited by-同舟云学术

T Lymphocytes in Parkinson’s Disease

Published:2022-09-27 Issue:s1 Volume:12 Page:S65-S74
ISSN:1877-7171
Container-title:Journal of Parkinson's Disease
language:
Short-container-title:JPD

Author:

Contaldi Elena¹²,Magistrelli Luca¹³,Comi Cristoforo⁴

Affiliation:

1. Department of Translational Medicine, Movement Disorders Centre, University Hospital ‘Maggiore della Caritá’, University of Piemonte Orientale, Novara, Italy

2. Program in Medical Sciences and Biotechnology, University of Piemonte Orientale, Novara, Italy

3. Program in Clinical and Experimental Medicine and Medical Humanities, University of Insubria, Varese, Italy

4. Department of Translational Medicine, Neurology Unit, S. Andrea Hospital, University of Piemonte Orientale, Vercelli, Italy

Abstract

T cells are key mediators of both humoral and cellular adaptive immune responses, and their role in Parkinson’s disease (PD) is being increasingly recognized. Several lines of evidence have highlighted how T cells are involved in both the central nervous system and the periphery, leading to a profound imbalance in the immune network in PD patients. This review discusses the involvement of T cells in both preclinical and clinical studies, their importance as feasible biomarkers of motor and non-motor progression of the disease, and recent therapeutic strategies addressing the modulation of T cell response.

Publisher

IOS Press

Subject

Cellular and Molecular Neuroscience,Neurology (clinical)

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