Construction of a prognostic signature of RFC5 immune-related genes in patients with cervical cancer

Author:

Chen Huaqiu123,Xie Huanyu23,Zhang Yuanyuan1,Wang Guangming1

Affiliation:

1. School of Clinical Medicine, Dali University, Dali, Yunnan, China

2. Xichang People’s Hospital, Xichang, Sichuan, China

3. Affiliated Hospital of Xichang College, Xichang, Sichuan, China

Abstract

BACKGROUND: Cervical cancer (CC) is a malignant tumor threatening women’s health. Replication factor C (RFC) 5 is significantly highly expressed in CC tissues, and the immune microenvironment plays a crucial role in tumor initiation, progression, and metastasis. OBJECTIVE: To determine the prognostic role of RFC5 in CC, analyze the immune genes significantly associated with RFC5, and establish a nomogram to evaluate the prognosis of patients with CC. METHODS: High RFC5 expression in patients with CC was analyzed and verified through TCGA GEO, TIMER2.0, and HPA databases. A risk score model was constructed using RFC5-related immune genes identified using R packages. Combining the risk score model and clinical information of patients with CC, a nomogram was constructed to evaluate the prognosis of patients with CC. RESULTS: Comprehensive analysis showed that the risk score was a prognostic factor for CC. The nomogram could predict the 3-year overall survival of patients with CC. CONCLUSIONS: RFC5 was validated as a biomarker for CC. The RFC5 related immune genes were used to establish a new prognostic model of CC.

Publisher

IOS Press

Subject

Cancer Research,Genetics,Oncology,General Medicine

Reference48 articles.

1. Cervical cancer: A global health crisis;Small;Cancer,2017

2. Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis;Arbyn;Lancet Global Health,2020

3. Involvement of human papillomaviruses in cervical cancer;Wang;Frontiers in Microbiology,2018

4. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries;Sung;CA: A Cancer Journal for Clinicians,2021

5. Changing cancer survival in China during 2003-15: a pooled analysis of 17 population-based cancer registries;Zeng;Lancet Global Health,2018

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