Translation of Pre-Clinical Studies into Successful Clinical Trials for Alzheimer’s Disease: What are the Roadblocks and How Can They Be Overcome?1

Author:

Banik Avijit1,Brown Richard E.2,Bamburg James3,Lahiri Debomoy K.4,Khurana Dheeraj1,Friedland Robert P.5,Chen Wei6,Ding Ying7,Mudher Amritpal8,Padjen Ante L.9,Mukaetova-Ladinska Elizabeta10,Ihara Masafumi11,Srivastava Sudhir12,Padma Srivastava M.V.13,Masters Colin L.14,Kalaria Raj N.10,Anand Akshay1

Affiliation:

1. Neuroscience Research Lab, Department of Neurology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

2. Department of Psychology and Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada

3. Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA

4. Departments of Psychiatry and of Medical & Molecular Genetics, Indiana University School of Medicine, Neuroscience Research Center, Indianapolis, IN, USA

5. Department of Neurology, University of Louisville, School of Medicine, Louisville, KY, USA

6. Division of Pulmonary Medicine, Allergy and Immunology, Children’s Hospital of Pittsburgh of the University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA, USA

7. Department of Biostatistics, University of Pittsburgh, 318C Parran Hall, Pittsburgh, PA, USA

8. Southampton Neurosciences Group, University of Southampton, Southampton, UK

9. Department of Pharmacology & Therapeutics, McGill University, Montreal, QC, Canada

10. Institute of Neuroscience, Newcastle University, NIHR Biomedical Research Building, Campus for Ageing and Vitality, Newcastle upon Tyne, UK

11. Department of Stroke and Cerebrovascular Diseases, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan

12. Division of Toxicology, Central Drug Research Institute, Lucknow, India

13. Department of Neurology, Neurosciences Centre, All India Institute of Medical Sciences, New Delhi, India

14. Mental Health Research Institute, University of Melbourne, Royal Parade, The VIC, Australia

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

Reference255 articles.

1. Epidemiology of Alzheimer disease;Reitz;Nat Rev Neurol,2011

2. 2013 Alzheimer’s disease facts and figures;Thies;Alzheimers Dement,2013

3. Prevalence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group;Lobo;Neurology,2000

4. Alzheimer’s disease and vascular dementia in developing countries: Prevalence, management, and risk factors;Kalaria;Lancet Neurol,2008

5. The global prevalence of dementia: A systematic review and metaanalysis;Prince;Alzheimers Dement,2013

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