Evaluation of a Genetic Risk Score to Improve Risk Prediction for Alzheimer’s Disease

Author:

Chouraki Vincent12,Reitz Christiane3,Maury Fleur4,Bis Joshua C.5,Bellenguez Celine4,Yu Lei6,Jakobsdottir Johanna7,Mukherjee Shubhabrata5,Adams Hieab H.8,Choi Seung Hoan9,Larson Eric B.510,Fitzpatrick Annette5,Uitterlinden Andre G.8,de Jager Philip L.11,Hofman Albert8,Gudnason Vilmundur712,Vardarajan Badri3,Ibrahim-Verbaas Carla8,van der Lee Sven J.8,Lopez Oscar13,Dartigues Jean-François14,Berr Claudine15,Amouyel Philippe4,Bennett David A.6,van Duijn Cornelia8,DeStefano Anita L.9,Launer Lenore J.16,Ikram M. Arfan8,Crane Paul K.510,Lambert Jean-Charles4,Mayeux Richard3,Seshadri Sudha12,

Affiliation:

1. Department of Neurology, Boston University School of Medicine, Boston, MA, USA

2. The Framingham Heart Study, Framingham, MA, USA

3. Columbia University, New York, NY, USA

4. Lille University, Inserm, Lille University Hospital, Institut Pasteur de Lille, U1167 - RID-AGE - Risk factors and molecular determinants of aging-related diseases; Labex Distalz, Lille, France

5. University of Washington, Seattle, WA, USA

6. Rush Alzheimer’s Disease Center, Chicago, IL, USA

7. Icelandic Heart Association, Kopavogur, Iceland

8. Erasmus Medical Center, Rotterdam, The Netherlands

9. Boston University School of Public Health, Boston, MA, USA

10. Group Health Research Institute, Seattle, WA, USA

11. Program in Translational NeuroPsychiatric Genomics, Departments of Neurology & Psychiatry, Brigham and Women’s Hospital, MA, USA

12. Faculty of Medicine, University of Iceland, Reykjavik, Iceland

13. Alzheimer’s Disease Research Center, Departments of Neurology, Psychiatry and Psychology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

14. Inserm U1219, Bordeaux Population Health, University of Bordeaux, Bordeaux, France

15. Inserm U1061 ‘Neuropsychiatry: epidemiological and clinical research’, Université de Montpellier, Monpellier, France

16. National Institute on Aging, Bethesda, MD, USA

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

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3. Genetic Complexities of Cerebral Small Vessel Disease, Blood Pressure, and Dementia;JAMA Network Open;2024-05-22

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