Association Between Neuropsychiatric Symptoms and Functional Change in Older Non-Demented Adults: Mayo Clinic Study of Aging-Reference-Cited by-同舟云学术

Association Between Neuropsychiatric Symptoms and Functional Change in Older Non-Demented Adults: Mayo Clinic Study of Aging

Published:2020-11-24 Issue:3 Volume:78 Page:911-917
ISSN:1387-2877
Container-title:Journal of Alzheimer's Disease
language:
Short-container-title:JAD

Author:

Krell-Roesch Janina¹²,Syrjanen Jeremy A.¹,Mielke Michelle M.¹³,Christianson Teresa J.¹,Kremers Walter K.¹,Machulda Mary M.⁴,Knopman David S.³,Petersen Ronald C.¹³,Vassilaki Maria¹,Geda Yonas E.⁵

Affiliation:

1. Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA

2. Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany

3. Department of Neurology, Mayo Clinic, Rochester, MN, USA

4. Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA

5. Department of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA

Abstract

We examined the associations between baseline neuropsychiatric symptoms (NPS) and longitudinal changes in functional performance among 5,394 non-demented individuals aged ≥50 years (2,729 males; median age 74.2 years; 4,716 cognitively unimpaired, 678 mild cognitive impairment). After adjusting for age, sex, education, and medical comorbidities, NPS assessed by the Neuropsychiatric Inventory Questionnaire, clinical depression (Beck Depression Inventory score ≥13) and anxiety (Beck Anxiety Inventory score ≥10) were significantly associated with an increase in the Functional Activities Questionnaire score, indicating functional decline over time. This association may vary depending on the degree of cognitive impairment at baseline.

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

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