The Role of Variation at AβPP, PSEN1, PSEN2, and MAPT in Late Onset Alzheimer's Disease

Author:

Gerrish Amy1,Russo Giancarlo1,Richards Alexander1,Moskvina Valentina1,Ivanov Dobril1,Harold Denise1,Sims Rebecca1,Abraham Richard1,Hollingworth Paul1,Chapman Jade1,Hamshere Marian1,Pahwa Jaspreet Singh1,Dowzell Kimberley1,Williams Amy1,Jones Nicola1,Thomas Charlene1,Stretton Alexandra1,Morgan Angharad R.1,Lovestone Simon2,Powell John3,Proitsi Petroula3,Lupton Michelle K.3,Brayne Carol4,Rubinsztein David C.5,Gill Michael6,Lawlor Brian6,Lynch Aoibhinn6,Morgan Kevin7,Brown Kristelle S.7,Passmore Peter A.8,Craig David8,McGuinness Bernadette8,Todd Stephen8,Johnston Janet A.8,Holmes Clive9,Mann David10,Smith A. David11,Love Seth12,Kehoe Patrick G.12,Hardy John13,Mead Simon14,Fox Nick15,Rossor Martin15,Collinge John14,Maier Wolfgang16,Jessen Frank16,Kölsch Heike16,Heun Reinhard1617,Schürmann Britta16,Bussche Hendrik van den18,Heuser Isabella19,Kornhuber Johannes20,Wiltfang Jens21,Dichgans Martin2223,Frölich Lutz24,Hampel Harald25,Hüll Michael26,Rujescu Dan26,Goate Alison M.27,Kauwe John S. K28,Cruchaga Carlos27,Nowotny Petra27,Morris John C.27,Mayo Kevin27,Livingston Gill29,Bass Nicholas J.29,Gurling Hugh29,McQuillin Andrew29,Gwilliam Rhian30,Deloukas Panagiotis30,Davies Gail3132,Harris Sarah E.3133,Starr John M.3134,Deary Ian J.3132,Al-Chalabi Ammar35,Shaw Christopher E.35,Tsolaki Magda36,Singleton Andrew B.37,Guerreiro Rita37,Mühleisen Thomas W.3839,Nöthen Markus M.3839,Moebus Susanne40,Jöckel Karl-Heinz40,Klopp Norman41,Wichmann H-Erich414243,Carrasquillo Minerva M44,Pankratz V Shane45,Younkin Steven G.44,Jones Lesley1,Holmans Peter A1,O'Donovan Michael C.1,Owen Michael J.1,Williams Julie1

Affiliation:

1. MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK

2. King's College London, Institute of Psychiatry, Kings College, London, UK

3. Department of Neuroscience, Institute of Psychiatry, Kings College, London, UK

4. Institute of Public Health, University of Cambridge, Cambridge, UK

5. Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK

6. Mercer's Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland

7. Human Genetics Group, School of Molecular Medical Sciences, Queen's Medical Centre, University of Nottingham, UK

8. Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, UK

9. Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK

10. Neurodegeneration and Mental Health Research Group, School of Community Based Medicine, University of Manchester, Salford, UK

11. Oxford Project to Investigate Memory and Ageing, University of Oxford, John Radcliffe Hospital, Oxford, UK

12. Dementia Research Group, University of Bristol Institute of Clinical Neurosciences, Frenchay Hospital, Bristol, UK

13. Department of Molecular Neuroscience and Reta Lilla Weston Laboratories, Institute of Neurology, London, UK

14. MRC Prion Unit and Department of Neurodegenerative Disease, Institute of Neurology, University College London

15. Dementia Research Centre, Department of Neurodegenerative Diseases, UCL Institute of Neurology, London, UK

16. Department of Psychiatry, University of Bonn, Bonn, Germany

17. Radbourne Unit, Royal Derby Hospital, Derby, UK

18. Institute of Primary Medical Care, University Medical Center Hamburg-Eppendorf, Germany

19. Department of Psychiatry, Charit'e Berlin, Berlin, Germany

20. Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Germany

21. LVR-Hospital Essen, Department of Psychiatry and Psychotherapy, University Duisburg-Essen, Germany

22. Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany

23. Department of Neurology, Klinikum der Universität München, Munich, Germany

24. Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany

25. Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany

26. Ludwig-Maximilians-University, Department of Psychiatry, Munich, Germany

27. Departments of Psychiatry, Neurology and Genetics, Washington University School of Medicine, St. Louis, Missouri, USA

28. Department of Biology, Brigham Young University, Provo, Utah, USA

29. Mental Health Unit, UCL, London, UK

30. The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

31. Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK

32. Department of Psychology, University of Edinburgh, Edinburgh, UK

33. Medical Genetics, Molecular Medicine Centre, University of Edinburgh, Edinburgh, UK

34. Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK

35. MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, Department of Clinical Neuroscience, London, UK

36. Third Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece

37. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA

38. Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany

39. Institute of Human Genetics, University of Bonn, Bonn, Germany

40. Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany

41. Institute of Epidemiology, Helmholtz Zentrum M¨nchen, German Research Center for Environmental Health, Neuherberg, Germany

42. Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany

43. Klinikum Grosshadern, Munich, Germany

44. Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, USA

45. Division of Biomedical Statistics and Informatics, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

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