The CALHM1 P86L Polymorphism is a Genetic Modifier of Age at Onset in Alzheimer's Disease: a Meta-Analysis Study

Author:

Lambert Jean-Charles123,Sleegers Kristel45,González-Pérez Antonio6,Ingelsson Martin7,Beecham Gary W.8,Hiltunen Mikko9,Combarros Onofre10,Bullido Maria J.11,Brouwers Nathalie45,Bettens Karolien45,Berr Claudine12,Pasquier Florence313,Richard Florence12313,DeKosky Steven T.14,Hannequin Didier15,Haines Jonathan L.16,Tognoni Gloria17,Fiévet Nathalie12,Dartigues Jean-François18,Tzourio Christophe1920,Engelborghs Sebastiaan521,Arosio Beatrice22,Coto Elicer23,De Deyn Peter521,Del Zompo Maria24,Mateo Ignacio10,Boada Merce2526,Antunez Carmen2728,Lopez-Arrieta Jesus29,Epelbaum Jacques30,Schjeide Brit-Maren Michaud31,Frank-Garcia Ana32,Giedraitis Vilmentas7,Helisalmi Seppo10,Porcellini Elisa33,Pilotto Alberto34,Forti Paola35,Ferri Raffaele36,Delepine Marc37,Zelenika Diana37,Lathrop Mark3738,Scarpini Elio39,Siciliano Gabriele17,Solfrizzi Vincenzo40,Sorbi Sandro41,Spalletta Gianfranco42,Ravaglia Giovanni35,Valdivieso Fernando11,Vepsäläinen Saila7,Alvarez Victoria23,Bosco Paolo36,Mancuso Michelangelo17,Panza Francesco40,Nacmias Benedetta41,Bossù Paola42,Hanon Olivier30,Piccardi Paola24,Annoni Giorgio43,Mann David44,Marambaud Philippe4546,Seripa Davide34,Galimberti Daniela39,Tanzi Rudolph E47,Bertram Lars31,Lendon Corinne48,Lannfelt Lars7,Licastro Federico33,Campion Dominique15,Pericak-Vance Margaret A.8,Soininen Hilkka9,Van Broeckhoven Christine54,Alpérovitch Annick1920,Ruiz Agustin6,Kamboh M. Ilyas49,Amouyel Philippe12313

Affiliation:

1. INSERM U744, Lille, France

2. Institut Pasteur de Lille, Lille, France

3. Université de Lille Nord de France, Lille, France

4. Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerp, Belgium

5. Institute Born-Bunge and University of Antwerp, Antwerp, Belgium

6. Department of Structural Genomics. Neocodex, Sevilla, Spain

7. Uppsala University, Stockholm, Sweden

8. John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, FL, USA

9. Department of Neurology, Kuopio University and University Hospital, Kuopio, Finland

10. Neurology Service and CIBERNED, "Marqués de Valdecilla" University Hospital (University of Cantabria), Santander, Spain

11. Centro de Biologia Molecular Severo Ochoa (UAM-CSIC) and CIBERNED, Universidad Autonoma, Cantoblanco, Madrid, Spain

12. INSERM U888, Hôpital La Colombière, Montpellier, France

13. CHRU de Lille, Lille, France

14. University of Virginia School of medicine, Charlottesville, VA, USA

15. INSERM U614, Faculté de Médecine-Pharmacie de Rouen, Rouen, France

16. Vanderbilt Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN, USA

17. Department of Neuroscience, Neurological Clinic, University of Pisa, Pisa, Italy

18. INSERM U897, Victor Segalen University, Bordeaux, France

19. INSERM U708, Paris, France

20. UPMC Univ. Paris 06, Paris, France

21. Memory Clinic and Department of Neurology, ZNA Middelheim, Antwerpen, Belgium

22. Department of Internal Medicine, Fondazione Policlinico IRCCS, Milan, Italy

23. Genetic Molecular Unit, Hospital Universitario Central de Asturias, Oviedo, Spain

24. Section of Clinical Pharmacology, Department of Neuroscience, University of Cagliari, Cagliari, Italy

25. Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain

26. Neurology Department, Hospital G. Universitari Vall d'Hebron, Barcelona, Spain

27. Alzheimur Foundation, Murcia, Spain

28. Dementia Unit. University Hospital Virgen de la Arrixaca, Murcia, Spain

29. Memory Unit. University Hospital La Paz- Cantoblanco, Madrid, Spain

30. UMR 894, INSERM Faculté de Médecine, Université Paris Descartes, Paris, France

31. Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max-Planck Institute for Molecular Genetics, Berlin, Germany

32. Servicio de Neurologia, Hospital Universitario La Paz (UAM) and CIBERNED, Madrid, Spain

33. Department of Experimental Pathology, School of Medicine, University of Bologna, Bologna, Italy

34. Geriatric Unit & Gerontology-Geriatric Research Laboratory, Department of Medical Science, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy

35. Department of Internal Medicine Cardiology and Hepatology, University Hospital S. Orsola-Malpighi, Bologna, Italy

36. IRCCS Oasi Maria SS, Troina, Italy

37. Centre National de Genotypage, Institut Genomique, Commissariat à l'Énergie Atomique, Evry, France

38. Fondation Jean Dausset-CEPH, Paris, France

39. Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan, Italy

40. Department of Geriatrics, Centre for Aging Brain, Memory Unit, University of Bari, Policlinico, Bari, Italy

41. Department of Neurological and Psychiatric Sciences, Florence, Italy

42. Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Roma, Italy

43. Department of Clinical Medicine and Prevention, University of Milano-Bicocca, Monza, Italy

44. Greater Manchester Neuroscience Centre, University of Manchester, Manchester, UK

45. Litwin-Zucker Research Center for the Study of Alzheimer's Disease, Feinstein Institute for Medical Research, North Shore-LIJ, Manhasset, NY, USA

46. Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA

47. Genetics and Aging Research Unit, Massachusetts General Hospital, Charlestown, MA, USA

48. Molecular Psychiatry Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Queensland, Australia

49. Department of Human Genetics and Alzheimer's Disease Research Centre, University of Pittsburgh, Pittsburgh, PA, USA

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

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